Gene · 7272
TTK: TTK protein kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TTK: TTK protein kinase. Genes, record 7272. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7272
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P33981 | Dual specificity protein kinase TTK | 857 | 78 | Ensembl, GeneID, HGNC |
Source UniProt
Patents99
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68480 | P33981 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8862 | P33981 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5472 | P33981 | Espacenet |
| US 12454559 B2 | 2025-10-28 | 1 | P33981 | Espacenet |
| JP 2025100656 A | 2025-07-03 | 4 | P33981 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8862 | P33981 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5472 | P33981 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 93320 | P33981 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 836 | P33981 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 196291 | P33981 | Espacenet |
1 to 10 of 99
See all 99 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials2
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02366949 | BAY-1217389 | PHASE1 | ClinicalTrials.gov | |
| NCT02138812 | BAY-1161909 | PHASE1 | ClinicalTrials.gov |
NIH grants1,509
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TTK papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 25 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01GM058015 | Recombinational Mechanisms of DNA Repair | 8 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 8 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 7 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 6 | 2025 |
1 to 10 of 1,509Source NIH's project files
See all 1,509 nih grantsPapers3,094
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of a Novel homozygous Splice-Site Deletion in KCTD7 Gene Associated with Progressive Myoclonic Epilepsy. | Pak J Med Sci | 2026 | 42818968 | PubTator, text mining | PubMed |
| AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma. | Hum Genomics | 2026 | 42800881 | PubTator, text mining | PubMed |
| Chromosomal Heterogeneity and Enrichment of Mitotic Regulatory Programs Reveal a Therapeutic Vulnerability in Cytarabine-Resistant FLT3-ITD AML. | Curr Issues Mol Biol | 2026 | 42793322 | PubTator, text mining | PubMed |
| Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation. | Medicine (Baltimore) | 2026 | 42675738 | PubTator, text mining | PubMed |
| Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer. | Cancer Res Commun | 2026 | 42647139 | PubTator, text mining | PubMed |
| Rewiring mitotic checkpoint control via Mps1 inhibition overcomes DNA repair-mediated resistance in glioblastoma. | J Biol Chem | 2026 | 42641883 | PubTator, text mining | PubMed |
| Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer. | bioRxiv | 2026 | 42619900 | PubTator, text mining | PubMed |
| A six-gene prognostic signature for aflatoxin B1-associated hepatocellular carcinoma identified through integrated bioinformatics and network toxicology. | Transl Gastroenterol Hepatol | 2026 | 42592322 | PubTator, text mining | PubMed |
| Characterizing risk groups in papillary thyroid carcinoma through T-Cell mediated tumor cell killing-related genes: a pathway to therapeutic predictions. | Eur Arch Otorhinolaryngol | 2026 | 42507215 | PubTator, text mining | PubMed |
| PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation. | Leukemia | 2026 | 42443409 | PubTator, text mining | PubMed |
1 to 10 of 3,094
See all 3,094 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7272
GET https://conductscience.org/api/genes/v1/7272/patents?page=2