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Gene · 7272

TTK: TTK protein kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TTK: TTK protein kinase. Genes, record 7272. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7272

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Gene

Symbol
TTK
HGNC
Name
TTK protein kinase
HGNC
NCBI Gene ID
7272
NCBI Gene
HGNC ID
HGNC:12401
HGNC
Ensembl
ENSG00000112742
NCBI Gene
Aliases
CT96, ESK, MPH1, MPS1, MPS1L1, PYT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P33981Dual specificity protein kinase TTK85778Ensembl, GeneID, HGNC

Source UniProt

Patents99

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468480P33981Espacenet
EP 4641201 A22025-10-298862P33981Espacenet
EP 4641202 A22025-10-295472P33981Espacenet
US 12454559 B22025-10-281P33981Espacenet
JP 2025100656 A2025-07-034P33981Espacenet
JP 2025517969 A2025-06-128862P33981Espacenet
KR 1020250017231 A2025-02-045472P33981Espacenet
US 11446398 B22022-09-2093320P33981Espacenet
JP 2022092366 A2022-06-22836P33981Espacenet
JP 2022524081 A2022-04-27196291P33981Espacenet

1 to 10 of 99

See all 99 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAY-1161909CHEMBL4303241Dual specificity protein kinase TTK inhibitorINHIBITORChEMBL
BAY-1217389CHEMBL4456085Dual specificity protein kinase TTK inhibitorINHIBITORChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02366949BAY-1217389PHASE1ClinicalTrials.gov
NCT02138812BAY-1161909PHASE1ClinicalTrials.gov

NIH grants1,509

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTTK papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
P30CA014520UW Comprehensive Cancer Center Support92025
P30CA016672Cancer Center Support Grant92025
R01GM058015Recombinational Mechanisms of DNA Repair82025
R01GM074215Kinetochore Specification and Function82025
P30CA015704Cancer Center Support Grant72025
P30CA016086Cancer Center Support Grant72025
P01CA092584Structural Cell Biology of DNA Repair Machines62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA014051Cancer Center Support (Core) Grant62025

1 to 10 of 1,509Source NIH's project files

See all 1,509 nih grants

Papers3,094

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of a Novel homozygous Splice-Site Deletion in KCTD7 Gene Associated with Progressive Myoclonic Epilepsy.Pak J Med Sci202642818968PubTator, text miningPubMed
AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma.Hum Genomics202642800881PubTator, text miningPubMed
Chromosomal Heterogeneity and Enrichment of Mitotic Regulatory Programs Reveal a Therapeutic Vulnerability in Cytarabine-Resistant FLT3-ITD AML.Curr Issues Mol Biol202642793322PubTator, text miningPubMed
Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation.Medicine (Baltimore)202642675738PubTator, text miningPubMed
Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.Cancer Res Commun202642647139PubTator, text miningPubMed
Rewiring mitotic checkpoint control via Mps1 inhibition overcomes DNA repair-mediated resistance in glioblastoma.J Biol Chem202642641883PubTator, text miningPubMed
Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer.bioRxiv202642619900PubTator, text miningPubMed
A six-gene prognostic signature for aflatoxin B1-associated hepatocellular carcinoma identified through integrated bioinformatics and network toxicology.Transl Gastroenterol Hepatol202642592322PubTator, text miningPubMed
Characterizing risk groups in papillary thyroid carcinoma through T-Cell mediated tumor cell killing-related genes: a pathway to therapeutic predictions.Eur Arch Otorhinolaryngol202642507215PubTator, text miningPubMed
PLK1 inhibition enhances Brentuximab vedotin efficacy in CD30-positive T-cell lymphoma via spindle assembly checkpoint activation.Leukemia202642443409PubTator, text miningPubMed

1 to 10 of 3,094

See all 3,094 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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