ConductScience.org, home

Library / Genes

TTR: transthyretin

1 protein, 205 patents, 13 drugs, 24 trials, 5,515 NIH grants and 15,593 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTTRHGNC
NametransthyretinHGNC
NCBI Gene ID7276NCBI Gene
HGNC IDHGNC:12405HGNC
EnsemblENSG00000118271NCBI Gene
AliasesAMYLD1, ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, TTNNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P02766Transthyretin147462Ensembl, GeneID, HGNCUniProt

Patents 205

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21138P02766Espacenet
EP 4705273 A22026-03-11638P02766Espacenet
JP 2026504449 A2026-02-0520P02766Espacenet
JP 2025540181 A2025-12-11164P02766Espacenet
EP 4658295 A22025-12-1020P02766Espacenet
JP 2025172742 A2025-11-264P02766Espacenet
EP 4650780 A22025-11-19931P02766Espacenet
JP 2025169942 A2025-11-141332P02766Espacenet
JP 2025147176 A2025-10-0613822P02766Espacenet
EP 4615425 A12025-09-1723P02766Espacenet

Drugs 13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACORAMIDISCHEMBL3940890Transthyretin stabiliserSTABILISERChEMBL
ACORAMIDIS HYDROCHLORIDECHEMBL4650226Transthyretin stabiliserSTABILISERChEMBL
EPLONTERSENCHEMBL4594334Transthyretin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
EPLONTERSEN SODIUMCHEMBL4594335Transthyretin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
INOTERSENCHEMBL4297770Transthyretin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
INOTERSEN SODIUMCHEMBL4297537Transthyretin mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
PATISIRANCHEMBL3989987Transthyretin mRNA RNAi inhibitorRNAI INHIBITORChEMBL
PATISIRAN SODIUMCHEMBL4297536Transthyretin mRNA RNAi inhibitorRNAI INHIBITORChEMBL
REVUSIRANCHEMBL4594492Transthyretin mRNA RNAi inhibitorRNAI INHIBITORChEMBL
TAFAMIDISCHEMBL2103837Transthyretin stabiliserSTABILISERChEMBL

Trials 24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06940336TAFAMIDIS MEGLUMINEPHASE4ClinicalTrials.gov
NCT06465810EPLONTERSENClinicalTrials.gov
NCT05505838PATISIRANClinicalTrials.gov
NCT05139680TAFAMIDIS2024-09-19ClinicalTrials.gov
NCT05139680TAFAMIDIS MEGLUMINE2024-09-19ClinicalTrials.gov
NCT05071300EPLONTERSENPHASE3ClinicalTrials.gov
NCT05023889PATISIRANEARLY_PHASE1ClinicalTrials.gov
NCT04882735ACORAMIDISPHASE3ClinicalTrials.gov
NCT04828993TAFAMIDIS MEGLUMINEPHASE42024-03-12ClinicalTrials.gov
NCT04418024ACORAMIDISPHASE3ClinicalTrials.gov

NIH grants 5515

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK046335Probing the biochemical mechanism of amyloid disease1012,025NIH's project files
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation302,025NIH's project files
P30ES005605Environmental Health Sciences Research Center282,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
P30CA016672Cancer Center Support Grant172,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award162,025NIH's project files
P50CA186781Mayo Clinic Multiple Myeloma SPORE132,025NIH's project files
P30CA086862Cancer Center Support Grant112,025NIH's project files
R01DK124211Molecular mechanisms of transthyretin amyloidosis102,025NIH's project files
R01HL160892IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELE102,025NIH's project files

Papers 15593

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818249PubTator, text miningPubMed
42814301PubTator, text miningPubMed
42814300PubTator, text miningPubMed
42812076PubTator, text miningPubMed
42809067PubTator, text miningPubMed
42807538PubTator, text miningPubMed
42799942PubTator, text miningPubMed
42799727PubTator, text miningPubMed
42788550PubTator, text miningPubMed
42787908PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license