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Gene · 7277

TUBA4A: tubulin alpha 4a

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TUBA4A: tubulin alpha 4a. Genes, record 7277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7277

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Gene

Symbol
TUBA4A
HGNC
Name
tubulin alpha 4a
HGNC
NCBI Gene ID
7277
NCBI Gene
HGNC ID
HGNC:12407
HGNC
Ensembl
ENSG00000127824
NCBI Gene
Aliases
ALS22, CMYO26, FLJ30169, FTDALS9, H2-ALPHA, OZEMA23, SPAX11, TUBA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P68366Tubulin alpha-4A chain4480Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-294438P68366Espacenet
JP 2025138725 A2025-09-251886P68366Espacenet
KR 1020250017231 A2025-02-044438P68366Espacenet
JP 2023145599 A2023-10-111886P68366Espacenet
JP 2023516705 A2023-04-20103P68366Espacenet
US 11446398 B22022-09-2093561P68366Espacenet
US 11357824 B22022-06-14970P68366Espacenet
JP 2022524081 A2022-04-27196532P68366Espacenet
JP 2022023036 A2022-02-0714498P68366Espacenet
WO 2021175788 A12021-09-10103P68366Espacenet

1 to 10 of 61

See all 61 patents

Drugs90

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGS-16C3FCHEMBL4594455Tubulin disrupting agentDISRUPTING AGENTChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Tubulin inhibitorINHIBITORChEMBL
ANG1005CHEMBL1089636Tubulin inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Tubulin inhibitorINHIBITORChEMBL
APRUTUMAB IXADOTINCHEMBL4650293Tubulin inhibitorINHIBITORChEMBL
ASG-5MECHEMBL2109574Tubulin inhibitorINHIBITORChEMBL
AVE-9633CHEMBL2109266Tubulin inhibitorINHIBITORChEMBL
AZINTUXIZUMAB VEDOTINCHEMBL4297859Tubulin inhibitorINHIBITORChEMBL
BELANTAMAB MAFODOTINCHEMBL4298209Tubulin inhibitorINHIBITORChEMBL
BIIB-015CHEMBL2109575Tubulin inhibitorINHIBITORChEMBL

1 to 10 of 90

See all 90 drugs

Trials8,728

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766PACLITAXELPHASE3ClinicalTrials.gov
NCT07602907PACLITAXELPHASE2ClinicalTrials.gov
NCT07601737PACLITAXELPHASE2ClinicalTrials.gov
NCT07601178PACLITAXELPHASE2ClinicalTrials.gov
NCT07599163PACLITAXELClinicalTrials.gov
NCT07595770PACLITAXELPHASE2ClinicalTrials.gov
NCT07594548PACLITAXELPHASE1ClinicalTrials.gov
NCT07591467DOCETAXELPHASE3ClinicalTrials.gov
NCT07589972VINORELBINEClinicalTrials.gov
NCT07588698VINCRISTINE SULFATEPHASE2ClinicalTrials.gov

1 to 10 of 8,728

See all 8,728 trials

NIH grants1,181

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTUBA4A papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)42025
R01GM058921Histone mRNA Regulation in Development42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R01NS120926Creating a foundation for personalized age- and sex-based immune-targeted therapies from an ALS longitudinal cohort by identifying peripheral and central immune signatures32025
R35GM118093Structural and functional studies of mRNA processing, stability and quality control32025
R35GM133552Coordination of chaperone interactions that dictate protein folding and trafficking32025
U01HG011755Broad Institute Mendelian Genomic Research Center32025

1 to 10 of 1,181Source NIH's project files

See all 1,181 nih grants

Papers2,174

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TUBA4A Pathogenic Variant Manifesting With Adulthood-Onset Genetic Myasthenic Syndrome, Myopathy, and Infertility.Eur J Neurol202642725680PubTator, text miningPubMed
Proteomic and metabolomic analysis of human follicular fluid from follicles with different diameters.Front Cell Dev Biol202642597911PubTator, text miningPubMed
A diagnostic signature derived from NK cell related genes in prostate cancer: insights from integrated scRNA-seq and bulk RNA-seq analyses with functional validation of KIT.Front Immunol202642317356PubTator, text miningPubMed
Multi-omics profiling characterizes the primary cilium-related molecular regulatory landscape in systemic lupus erythematosus.Analyst202642312723PubTator, text miningPubMed
Deciphering the role of tubulin's C-terminal tail in kinesin binding using computational and clustering approaches.Sci Rep202642168523PubTator, text miningPubMed
Deciphering cis-regulatory elements using REgulamentary.Bioinform Adv202641943802PubTator, text miningPubMed
Human-Robot Interaction Strategy of Service Robot with Insufficient Capability in Self-Service Shop.Biomimetics (Basel)202641892136PubTator, text miningPubMed
Imaging improvements reveal guttae development and posterior fibrillar layer formation in fuchs endothelial corneal dystrophy.Sci Rep202641888247PubTator, text miningPubMed
Microtubules guide Aurora B substrate geometries for accurate chromosome segregation.Sci Adv202641880487PubTator, text miningPubMed
Construction and Validation of an N7-Methylguanosine-Related Prognostic Model for Acute Myeloid Leukemia.Blood Lymphat Cancer202641847631PubTator, text miningPubMed

1 to 10 of 2,174

See all 2,174 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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