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C5AR1: complement C5a receptor 1

1 protein, 31 patents, 2 drugs, 19 trials, 5,123 NIH grants and 13,454 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolC5AR1HGNC
Namecomplement C5a receptor 1HGNC
NCBI Gene ID728NCBI Gene
HGNC IDHGNC:1338HGNC
EnsemblENSG00000197405NCBI Gene
AliasesC5A, C5AR, C5R1, CD88NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21730C5a anaphylatoxin chemotactic receptor 135019Ensembl, GeneID, HGNCUniProt

Patents 31

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641202 A22025-10-29387P21730Espacenet
JP 2025529142 A2025-09-04666P21730Espacenet
US 12371689 B22025-07-29666P21730Espacenet
JP 2025069140 A2025-04-301P21730Espacenet
KR 1020250017231 A2025-02-04387P21730Espacenet
US 12018072 B22024-06-251P21730Espacenet
JP 2023153821 A2023-10-189P21730Espacenet
JP 2023537417 A2023-08-311P21730Espacenet
KR 1020230045075 A2023-04-041P21730Espacenet
US 11446398 B22022-09-2019475P21730Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVACOPANCHEMBL3989871C5a anaphylatoxin chemotactic receptor antagonistANTAGONISTChEMBL
AVDORALIMABCHEMBL4594463C5a anaphylatoxin chemotactic receptor inhibitorINHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07556484AVACOPANPHASE1ClinicalTrials.gov
NCT07373262AVACOPANPHASE3ClinicalTrials.gov
NCT07176546AVACOPANPHASE2/PHASE3ClinicalTrials.gov
NCT06758271AVACOPANClinicalTrials.gov
NCT06676579AVACOPANPHASE2ClinicalTrials.gov
NCT06321601AVACOPANPHASE3ClinicalTrials.gov
NCT06072482AVACOPANPHASE4ClinicalTrials.gov
NCT04563923AVDORALIMABPHASE2ClinicalTrials.gov
NCT04371367AVDORALIMABPHASE2ClinicalTrials.gov
NCT04333914AVDORALIMABPHASE2ClinicalTrials.gov

NIH grants 5123

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition192,025NIH's project files
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis182,025NIH's project files
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies182,025NIH's project files
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology152,025NIH's project files
I01RX000444Complement Factor H-based Therapeutic Strategies in Macular Degeneration112,025NIH's project files
R01AI015614Pathogenesis of Fever in Man102,025NIH's project files
T32HL007317Principles in Pulmonary Research102,025NIH's project files
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center92,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files

Papers 13454

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820034PubTator, text miningPubMed
42819771PubTator, text miningPubMed
42812634PubTator, text miningPubMed
42794971PubTator, text miningPubMed
42794833PubTator, text miningPubMed
42780117PubTator, text miningPubMed
42769490PubTator, text miningPubMed
42737716PubTator, text miningPubMed
42735196PubTator, text miningPubMed
42734521PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license