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TWIST1: twist family bHLH transcription factor 1

1 protein, 46 patents, 0 drugs, 0 trials, 7,396 NIH grants and 21,433 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTWIST1HGNC
Nametwist family bHLH transcription factor 1HGNC
NCBI Gene ID7291NCBI Gene
HGNC IDHGNC:12428HGNC
EnsemblENSG00000122691NCBI Gene
AliasesACS3, BPES2, BPES3, CRS, CRS1, CSO, H-twist, SCS, SWCOS, TWIST, bHLHa38NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q15672Twist-related protein 12022Ensembl, GeneID, HGNCUniProt

Patents 46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2025172069 A2025-11-20745Q15672Espacenet
EP 4650780 A22025-11-191058Q15672Espacenet
JP 2025147176 A2025-10-0615816Q15672Espacenet
JP 2025521922 A2025-07-1049Q15672Espacenet
JP 2025517970 A2025-06-121058Q15672Espacenet
JP 2025506727 A2025-03-1359Q15672Espacenet
US 12247982 B22025-03-11745Q15672Espacenet
JP 2025028160 A2025-02-2815816Q15672Espacenet
KR 1020250010750 A2025-01-2115816Q15672Espacenet
JP 2024123008 A2024-09-108905Q15672Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7396

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1602,025NIH's project files
P30CA008748Cancer Center Support Grant572,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant372,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028262,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant262,025NIH's project files
P30CA006973Regional Oncology Research Center232,025NIH's project files
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant232,025NIH's project files
P30CA016086Cancer Center Support Grant222,025NIH's project files
P50CA058223SPORE in Breast Cancer222,025NIH's project files
P30CA016058Cancer Center Support Grant192,025NIH's project files

Papers 21433

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804651PubTator, text miningPubMed
42802034PubTator, text miningPubMed
42794700PubTator, text miningPubMed
42786628PubTator, text miningPubMed
42785447PubTator, text miningPubMed
42779759PubTator, text miningPubMed
42776424PubTator, text miningPubMed
42770181PubTator, text miningPubMed
42767446PubTator, text miningPubMed
42763930PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license