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TNFRSF4: TNF receptor superfamily member 4

1 protein, 647 patents, 5 drugs, 29 trials, 4,310 NIH grants and 8,300 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFRSF4HGNC
NameTNF receptor superfamily member 4HGNC
NCBI Gene ID7293NCBI Gene
HGNC IDHGNC:11918HGNC
EnsemblENSG00000186827NCBI Gene
AliasesACT35, CD134, IMD16, OX40, TXGP1LNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43489Tumor necrosis factor receptor superfamily member 42778Ensembl, GeneID, HGNCUniProt

Patents 647

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4806462 A22026-09-166P43489Espacenet
WO 2026183237 A12026-09-0385P43489Espacenet
WO 2026167093 A12026-08-1355P43489Espacenet
WO 2026167100 A12026-08-13142P43489Espacenet
JP 2026516142 A2026-05-1952P43489Espacenet
JP 2026516158 A2026-05-1911P43489Espacenet
JP 2026077646 A2026-05-1354P43489Espacenet
US RE050880 E12026-05-05176P43489Espacenet
JP 2026074200 A2026-05-01106P43489Espacenet
JP 2026514048 A2026-05-01176P43489Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GSK-3174998CHEMBL4297968Tumor necrosis factor receptor superfamily member 4 agonistAGONISTChEMBL
IVUXOLIMABCHEMBL4297883Tumor necrosis factor receptor superfamily member 4 agonistAGONISTChEMBL
MEDI-6469CHEMBL2109531Tumor necrosis factor receptor superfamily member 4 agonistAGONISTChEMBL
ROCATINLIMABCHEMBL4594567Tumor necrosis factor receptor superfamily member 4 antagonistANTAGONISTChEMBL
TELAZORLIMABCHEMBL4594546Tumor necrosis factor receptor superfamily member 4 antagonistANTAGONISTChEMBL

Trials 29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06527404ROCATINLIMABPHASE3ClinicalTrials.gov
NCT06376045ROCATINLIMABPHASE2ClinicalTrials.gov
NCT06224192ROCATINLIMABPHASE3ClinicalTrials.gov
NCT06160609GSK-3174998PHASE1/PHASE22024-03-12ClinicalTrials.gov
NCT05899816ROCATINLIMABPHASE3ClinicalTrials.gov
NCT05882877ROCATINLIMABPHASE3ClinicalTrials.gov
NCT05724199ROCATINLIMABPHASE3ClinicalTrials.gov
NCT05704738ROCATINLIMABPHASE3ClinicalTrials.gov
NCT05651711ROCATINLIMABPHASE3ClinicalTrials.gov
NCT05633355ROCATINLIMABPHASE3ClinicalTrials.gov

NIH grants 4310

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1012,025NIH's project files
P30CA016672Cancer Center Support Grant922,025NIH's project files
P50CA126752SPORE in Lymphoma322,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award272,025NIH's project files
P30CA047904Cancer Center Support Grant252,025NIH's project files
P30CA006973Regional Oncology Research Center242,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant212,025NIH's project files
U19AI142742Human immune memory to COVID-19, vaccines, and respiratory pathogens212,025NIH's project files
ZIABC010984Adoptive Cell Transfer Immunotherapy of Cancer182,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success172,025NIH's project files

Papers 8300

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823603PubTator, text miningPubMed
42815647PubTator, text miningPubMed
42804348PubTator, text miningPubMed
42800817PubTator, text miningPubMed
42776797PubTator, text miningPubMed
42769701PubTator, text miningPubMed
42761973PubTator, text miningPubMed
42752301PubTator, text miningPubMed
42737720PubTator, text miningPubMed
42702765PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license