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TXN: thioredoxin

1 protein, 167 patents, 1 drug, 2 trials, 7,508 NIH grants and 17,569 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTXNHGNC
NamethioredoxinHGNC
NCBI Gene ID7295NCBI Gene
HGNC IDHGNC:12435HGNC
EnsemblENSG00000136810NCBI Gene
AliasesTRDX, TRX, TRX1, TXN1, Trx80NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10599Thioredoxin10537Ensembl, GeneID, HGNCUniProt

Patents 167

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026501641 A2026-01-1610P10599Espacenet
JP 2025182217 A2025-12-1212P10599Espacenet
EP 4650780 A22025-11-199479P10599Espacenet
EP 4644410 A12025-11-0510P10599Espacenet
EP 4641202 A22025-10-295624P10599Espacenet
JP 2025531239 A2025-09-191P10599Espacenet
JP 2025526447 A2025-08-1350P10599Espacenet
EP 4587581 A22025-07-231P10599Espacenet
WO 2025146459 A22025-07-103P10599Espacenet
WO 2025146460 A12025-07-103P10599Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PX-12CHEMBL406050Thioredoxin inhibitorINHIBITORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00736372PX-12PHASE1ClinicalTrials.gov
NCT00417287PX-12PHASE2ClinicalTrials.gov

NIH grants 7508

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant412,025NIH's project files
P30CA086862Cancer Center Support Grant372,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30ES005605Environmental Health Sciences Research Center222,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)192,025NIH's project files
R37AG013925Effect of Aging on Preadipocyte Differentiation182,025NIH's project files
P01AG062413Targeting Cellular Senescence to Extend Healthspan172,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program172,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant172,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center162,025NIH's project files

Papers 17569

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817624PubTator, text miningPubMed
42816842PubTator, text miningPubMed
42810144PubTator, text miningPubMed
42801556PubTator, text miningPubMed
42792101PubTator, text miningPubMed
42775310PubTator, text miningPubMed
42762293PubTator, text miningPubMed
42757385PubTator, text miningPubMed
42748792PubTator, text miningPubMed
42734794PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license