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Gene · 7296

TXNRD1: thioredoxin reductase 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. TXNRD1: thioredoxin reductase 1. Genes, record 7296. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/7296

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
TXNRD1
HGNC
Name
thioredoxin reductase 1
HGNC
NCBI Gene ID
7296
NCBI Gene
HGNC ID
HGNC:12437
HGNC
Ensembl
ENSG00000198431
NCBI Gene
Aliases
GRIM-12, TR, TR1, TRXR1, TXNR, TXNR1, Trxr1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16881Thioredoxin reductase 1, cytoplasmic6499Ensembl, GeneID, HGNC

Source UniProt

Patents4

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2918853Q16881Espacenet
JP 2025517969 A2025-06-1218853Q16881Espacenet
EP 4484957 A12025-01-01230Q16881Espacenet
WO 2023162878 A2023-08-31230Q16881Espacenet

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARSENIC TRIOXIDECHEMBL5483015Thioredoxin reductase 1 inhibitorINHIBITORChEMBL
AUROTHIOGLUCOSECHEMBL1697725Thioredoxin reductase 1 inhibitorINHIBITORChEMBL
MOTEXAFIN GADOLINIUMCHEMBL3544910Thioredoxin reductase 1 inhibitorINHIBITORChEMBL

Trials159

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07503730ARSENIC TRIOXIDEPHASE3ClinicalTrials.gov
NCT07348107ARSENIC TRIOXIDEPHASE1ClinicalTrials.gov
NCT07296445ARSENIC TRIOXIDEPHASE3ClinicalTrials.gov
NCT07187505ARSENIC TRIOXIDEClinicalTrials.gov
NCT06933394ARSENIC TRIOXIDEPHASE2ClinicalTrials.gov
NCT06882031ARSENIC TRIOXIDEPHASE1ClinicalTrials.gov
NCT06778187ARSENIC TRIOXIDEPHASE2ClinicalTrials.gov
NCT06670222ARSENIC TRIOXIDEPHASE1ClinicalTrials.gov
NCT06450145ARSENIC TRIOXIDEClinicalTrials.gov
NCT06088030ARSENIC TRIOXIDEPHASE2ClinicalTrials.gov

1 to 10 of 159

See all 159 trials

NIH grants2,024

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30ES006694Southwest Environmental Health Sciences Center222025
P30CA016672Cancer Center Support Grant142025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant102025
T32ES007091Training in Environmental Toxicology of Human Disease102025
P30CA042014Cancer Center Support Grant72025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)72025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity72025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)62025
P30ES005605Environmental Health Sciences Research Center62025

1 to 10 of 2,024Source NIH's project files

See all 2,024 nih grants

Papers4,270

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807861PubTator, text miningPubMed
42783960PubTator, text miningPubMed
42767060PubTator, text miningPubMed
42758439PubTator, text miningPubMed
42757385PubTator, text miningPubMed
42737624PubTator, text miningPubMed
42723548PubTator, text miningPubMed
42722114PubTator, text miningPubMed
42709540PubTator, text miningPubMed
42689710PubTator, text miningPubMed

1 to 10 of 4,270

See all 4,270 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7296

GET https://conductscience.org/api/genes/v1/7296/trials?page=2