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TYK2: tyrosine kinase 2

1 protein, 45 patents, 18 drugs, 774 trials, 3,831 NIH grants and 7,661 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTYK2HGNC
Nametyrosine kinase 2HGNC
NCBI Gene ID7297NCBI Gene
HGNC IDHGNC:12440HGNC
EnsemblENSG00000105397NCBI Gene
AliasesIMD35, JTK1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29597Non-receptor tyrosine-protein kinase TYK21,18752Ensembl, GeneID, HGNCUniProt

Patents 45

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0356P29597Espacenet
JP 2026004568 A2026-01-1468804P29597Espacenet
JP 2026004568 A2026-01-1468805P29597Espacenet
EP 4640849 A22025-10-29290P29597Espacenet
EP 4641201 A22025-10-291982P29597Espacenet
JP 2025519096 A2025-06-24290P29597Espacenet
JP 2025517969 A2025-06-121982P29597Espacenet
US 12133879 B22024-11-0556P29597Espacenet
US 11957931 B22024-04-164P29597Espacenet
US 11884978 B22024-01-30786P29597Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BREPOCITINIBCHEMBL4297477Tyrosine-protein kinase TYK2 inhibitorINHIBITORChEMBL
CERDULATINIBCHEMBL4116008Tyrosine-protein kinase TYK2 inhibitorINHIBITORChEMBL
CRAVACITINIBCHEMBL4596392Tyrosine-protein kinase TYK2 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
DELGOCITINIBCHEMBL4297507Janus Kinase (JAK) inhibitorINHIBITORChEMBL
DEUCRAVACITINIBCHEMBL4435170Tyrosine-protein kinase TYK2 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
DEURUXOLITINIB PHOSPHATECHEMBL4594382Tyrosine-protein kinase TYK2 inhibitorINHIBITORChEMBL
FILGOTINIBCHEMBL3301607Tyrosine-protein kinase TYK2 inhibitorINHIBITORChEMBL
FILGOTINIB MALEATECHEMBL4298167Tyrosine-protein kinase TYK2 inhibitorINHIBITORChEMBL
GUSACITINIBCHEMBL4594275Janus Kinase (JAK) inhibitorINHIBITORChEMBL
IZENCITINIBCHEMBL4650343Janus Kinase (JAK) inhibitorINHIBITORChEMBL

Trials 774

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07598643TOFACITINIBPHASE2ClinicalTrials.gov
NCT07597577UPADACITINIBClinicalTrials.gov
NCT07595939RUXOLITINIBPHASE3ClinicalTrials.gov
NCT07588568UPADACITINIBPHASE2ClinicalTrials.gov
NCT07581418TOFACITINIBClinicalTrials.gov
NCT07576010RUXOLITINIBPHASE1ClinicalTrials.gov
NCT07566897RUXOLITINIBPHASE1ClinicalTrials.gov
NCT07564271DEUCRAVACITINIBClinicalTrials.gov
NCT07554820TOFACITINIBPHASE4ClinicalTrials.gov
NCT07554495FILGOTINIBPHASE3ClinicalTrials.gov

NIH grants 3831

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant412,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success402,025NIH's project files
P30CA008748Cancer Center Support Grant342,025NIH's project files
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases262,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)232,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files
P30CA016058Cancer Center Support Grant202,025NIH's project files
ZICAR041181Translational Immunology research: a support for clinical immunological research182,025NIH's project files
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis162,025NIH's project files
ZIAAI000646Transgenic Animal Models Of Human Immune Defects142,025NIH's project files

Papers 7661

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825998PubTator, text miningPubMed
42818629PubTator, text miningPubMed
42804788PubTator, text miningPubMed
42786248PubTator, text miningPubMed
42786200PubTator, text miningPubMed
42779165PubTator, text miningPubMed
42769975PubTator, text miningPubMed
42769501PubTator, text miningPubMed
42762643PubTator, text miningPubMed
42761984PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license