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TYMS: thymidylate synthetase

1 protein, 58 patents, 11 drugs, 5,574 trials, 3,937 NIH grants and 12,389 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTYMSHGNC
Namethymidylate synthetaseHGNC
NCBI Gene ID7298NCBI Gene
HGNC IDHGNC:12441HGNC
EnsemblENSG00000176890NCBI Gene
AliasesDKCD, HST422, HsT422, TMS, TS, TsaseNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04818Thymidylate synthase31361Ensembl, GeneID, HGNCUniProt

Patents 58

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467039P04818Espacenet
EP 4650780 A22025-11-195025P04818Espacenet
EP 4641202 A22025-10-294901P04818Espacenet
JP 2025147176 A2025-10-0616601P04818Espacenet
JP 2025517970 A2025-06-125025P04818Espacenet
JP 2025032204 A2025-03-1137921P04818Espacenet
JP 2025028160 A2025-02-2816601P04818Espacenet
KR 1020250017231 A2025-02-044901P04818Espacenet
KR 1020250010750 A2025-01-2116601P04818Espacenet
EP 4461818 A22024-11-1337921P04818Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAPECITABINECHEMBL1773Thymidylate synthase inhibitorINHIBITORChEMBL
DOXIFLURIDINECHEMBL1130Thymidylate synthase inhibitorINHIBITORChEMBL
FLOXURIDINECHEMBL917Thymidylate synthase inhibitorINHIBITORChEMBL
FLUOROURACILCHEMBL185Thymidylate synthase inhibitorINHIBITORChEMBL
NOLATREXEDCHEMBL320775Thymidylate synthase antagonistANTAGONISTChEMBL
OSI-7904CHEMBL169896Thymidylate synthase inhibitorINHIBITORChEMBL
PEMETREXEDCHEMBL225072Thymidylate synthase inhibitorINHIBITORChEMBL
PEMETREXED DISODIUMCHEMBL2360464Thymidylate synthase inhibitorINHIBITORChEMBL
PEMETREXED MONOHYDRATECHEMBL5315053Thymidylate synthase inhibitorINHIBITORChEMBL
RALTITREXEDCHEMBL225071Thymidylate synthase inhibitorINHIBITORChEMBL

Trials 5574

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603375FLUOROURACILPHASE2ClinicalTrials.gov
NCT07595913FLUOROURACILPHASE3ClinicalTrials.gov
NCT07594925CAPECITABINEPHASE2ClinicalTrials.gov
NCT07592819FLUOROURACILClinicalTrials.gov
NCT07591493CAPECITABINEPHASE3ClinicalTrials.gov
NCT07590024CAPECITABINEPHASE3ClinicalTrials.gov
NCT07586202PEMETREXEDPHASE2ClinicalTrials.gov
NCT07585279FLUOROURACILPHASE2/PHASE3ClinicalTrials.gov
NCT07584135CAPECITABINEPHASE3ClinicalTrials.gov
NCT07580339CAPECITABINEPHASE2ClinicalTrials.gov

NIH grants 3937

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016056Roswell Park Cancer Center Support Grant512,025NIH's project files
P30CA016058Cancer Center Support Grant442,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)382,025NIH's project files
P30CA016672Cancer Center Support Grant372,025NIH's project files
P30CA008748Cancer Center Support Grant362,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)302,025NIH's project files
P30CA012197Cancer Center Support Grant262,025NIH's project files
P30CA047904Cancer Center Support Grant202,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT182,025NIH's project files
P30CA016359Cancer Center Support Grant172,025NIH's project files

Papers 12389

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42809056PubTator, text miningPubMed
42801783PubTator, text miningPubMed
42794560PubTator, text miningPubMed
42781095PubTator, text miningPubMed
42771562PubTator, text miningPubMed
42752660PubTator, text miningPubMed
42726806PubTator, text miningPubMed
42689969PubTator, text miningPubMed
42675738PubTator, text miningPubMed
42653702PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license