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Gene · 7301

TYRO3: TYRO3 protein tyrosine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TYRO3: TYRO3 protein tyrosine kinase. Genes, record 7301. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7301

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Gene

Symbol
TYRO3
HGNC
Name
TYRO3 protein tyrosine kinase
HGNC
NCBI Gene ID
7301
NCBI Gene
HGNC ID
HGNC:12446
HGNC
Ensembl
ENSG00000092445
NCBI Gene
Aliases
BYK, Brt, Dtk, Etk-2, RSE, Rek, Sky, Tif
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q06418Tyrosine-protein kinase receptor TYRO38901Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468769Q06418Espacenet
EP 4641201 A22025-10-291825Q06418Espacenet
EP 4633648 A12025-10-2274Q06418Espacenet
JP 2025529142 A2025-09-045139Q06418Espacenet
US 12371689 B22025-07-295139Q06418Espacenet
JP 2025517969 A2025-06-121825Q06418Espacenet
EP 4547223 A22025-05-07220Q06418Espacenet
JP 2024099931 A2024-07-261Q06418Espacenet
US 11732048 B22023-08-2223Q06418Espacenet
US 11584796 B22023-02-2139Q06418Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,792

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTYRO3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant262025
P30CA046934University of Colorado Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant132025
P30CA016086Cancer Center Support Grant82025
P30CA014195Cancer Center Support Grant (CCSG)72025
UL1TR001863Yale Clinical and Translational Science Award72025
K24HL137013Mentoring Research in Precision Medicine for Lung Disease52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA006973Regional Oncology Research Center52025
P30CA016058Cancer Center Support Grant52025

1 to 10 of 1,792Source NIH's project files

See all 1,792 nih grants

Papers2,825

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
STELLAR-311: a randomized phase II/III study of zanzalintinib versus everolimus in advanced neuroendocrine tumors.Future Oncol202642803451PubTator, text miningPubMed
Aberrant expression of MERTK activates BCR via CD79a in CLL cells: alternative therapeutic strategy for relapsed/refractory CLL.Leukemia202642778661PubTator, text miningPubMed
Sagittal Alignment in Adolescent Idiopathic Scoliosis with Major Thoracic Curves: Pelvic Incidence and Its Influences on Lumbar Lordosis and Thoracic Kyphosis.Spine (Phila Pa 1976)202642773950PubTator, text miningPubMed
Structural organization of TAM receptor ectodomains.Biochem J202642770830PubTator, text miningPubMed
Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma.Adv Sci (Weinh)202642750190PubTator, text miningPubMed
Cross-organ crosstalk in brain-aging-related sarcopenia: Caudate iron accumulation impairs muscle health via blood-brain barrier dysfunction.Brain Res Bull202642748982PubTator, text miningPubMed
Expression of TAM receptors and their ligands in unexplained recurrent pregnancy loss.Immunol Res202642684543PubTator, text miningPubMed
Anticancer Effects of Cucurbitacin B and Meleagrin Associated with TYRO3 Downregulation in Colorectal Cancer Cells.Int J Mol Sci202642589416PubTator, text miningPubMed
Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer's disease therapy.Front Immunol202642523631PubTator, text miningPubMed
Receptor-Ligand Biomarker Profile in Ankylosing Spondylitis: Associations Between AXL/MERTK Expression, Circulating GAS6 and Protein S Levels, and Disease Activity.Life (Basel)202642514136PubTator, text miningPubMed

1 to 10 of 2,825

See all 2,825 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7301

GET https://conductscience.org/api/genes/v1/7301/patents?page=2