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Gene · 730249

ACOD1: aconitate decarboxylase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACOD1: aconitate decarboxylase 1. Genes, record 730249. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/730249

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Gene

Symbol
ACOD1
HGNC
Name
aconitate decarboxylase 1
HGNC
NCBI Gene ID
730249
NCBI Gene
HGNC ID
HGNC:33904
HGNC
Ensembl
ENSG00000102794
NCBI Gene
Aliases
CAD, IRG1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A6NK06Cis-aconitate decarboxylase4811Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2910193A6NK06Espacenet
JP 2025517969 A2025-06-1210193A6NK06Espacenet
JP 2025024198 A2025-02-1913020A6NK06Espacenet
JP 2023541632 A2023-10-0310A6NK06Espacenet
US 11446398 B22022-09-2040016A6NK06Espacenet
JP 2022524081 A2022-04-27142987A6NK06Espacenet
US 11078247 B22021-08-035583A6NK06Espacenet
US 9827332 B22017-11-2813020A6NK06Espacenet
JP 2017121243 A2017-07-1356988A6NK06Espacenet
US 9254311 B22016-02-0913020A6NK06Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,294

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACOD1 papersNewest fiscal year
P30CA068485Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant82025
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA016087Cancer Center Support Grant42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
R01CA077955H. Pylori Relationship to Digestive Diseases and Cancer42025
ZIABC010300Immunometabolism in Cancer and Inflammation42025
ZIACP000112Nutrition Intervention Trials42025

1 to 10 of 1,294Source NIH's project files

See all 1,294 nih grants

Papers2,030

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Advances in traditional Chinese medicine for modulating macrophage polarization in the treatment of rheumatoid arthritis.Front Pharmacol202642812562PubTator, text miningPubMed
Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and in vitro validation.Front Immunol202642812170PubTator, text miningPubMed
Itaconation and Succination as Metabolite-Derived Cysteine Modifications in Inflammatory Signalling: Biochemical Mechanisms, Chemoproteomic Mapping, and Therapeutic Opportunities.Cell Biochem Biophys202642776374PubTator, text miningPubMed
Itaconate metabolism in regulated cell death.Mol Cell Biochem202642766264PubTator, text miningPubMed
Integrated physiological, transcriptomic and metabolomic analysis reveals differential cold response in wheat seedlings across varieties.Front Plant Sci202642718787PubTator, text miningPubMed
Itaconate and its derivatives in human health and diseases.Signal Transduct Target Ther202642693110PubTator, text miningPubMed
Revisiting macrophage metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: mechanisms, regulation, and therapeutic breakthroughs.Front Immunol202642676633PubTator, text miningPubMed
CAD-RADS 2.0-guided diagnostic pathways in chronic coronary syndromes: a real-world Polish registry of over 10 000 patients.Kardiol Pol202642639957PubTator, text miningPubMed
Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate.J Struct Biol X202642631184PubTator, text miningPubMed
ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.Pathol Res Pract202642617477PubTator, text miningPubMed

1 to 10 of 2,030

See all 2,030 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/730249

GET https://conductscience.org/api/genes/v1/730249/patents