Gene · 730249
ACOD1: aconitate decarboxylase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACOD1: aconitate decarboxylase 1. Genes, record 730249. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/730249
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| A6NK06 | Cis-aconitate decarboxylase | 481 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 10193 | A6NK06 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10193 | A6NK06 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 13020 | A6NK06 | Espacenet |
| JP 2023541632 A | 2023-10-03 | 10 | A6NK06 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 40016 | A6NK06 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142987 | A6NK06 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5583 | A6NK06 | Espacenet |
| US 9827332 B2 | 2017-11-28 | 13020 | A6NK06 | Espacenet |
| JP 2017121243 A | 2017-07-13 | 56988 | A6NK06 | Espacenet |
| US 9254311 B2 | 2016-02-09 | 13020 | A6NK06 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,294
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACOD1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA068485 | Cancer Center Support Grant | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 7 | 2025 |
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 5 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
| R01CA077955 | H. Pylori Relationship to Digestive Diseases and Cancer | 4 | 2025 |
| ZIABC010300 | Immunometabolism in Cancer and Inflammation | 4 | 2025 |
| ZIACP000112 | Nutrition Intervention Trials | 4 | 2025 |
1 to 10 of 1,294Source NIH's project files
See all 1,294 nih grantsPapers2,030
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Advances in traditional Chinese medicine for modulating macrophage polarization in the treatment of rheumatoid arthritis. | Front Pharmacol | 2026 | 42812562 | PubTator, text mining | PubMed |
| Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and in vitro validation. | Front Immunol | 2026 | 42812170 | PubTator, text mining | PubMed |
| Itaconation and Succination as Metabolite-Derived Cysteine Modifications in Inflammatory Signalling: Biochemical Mechanisms, Chemoproteomic Mapping, and Therapeutic Opportunities. | Cell Biochem Biophys | 2026 | 42776374 | PubTator, text mining | PubMed |
| Itaconate metabolism in regulated cell death. | Mol Cell Biochem | 2026 | 42766264 | PubTator, text mining | PubMed |
| Integrated physiological, transcriptomic and metabolomic analysis reveals differential cold response in wheat seedlings across varieties. | Front Plant Sci | 2026 | 42718787 | PubTator, text mining | PubMed |
| Itaconate and its derivatives in human health and diseases. | Signal Transduct Target Ther | 2026 | 42693110 | PubTator, text mining | PubMed |
| Revisiting macrophage metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: mechanisms, regulation, and therapeutic breakthroughs. | Front Immunol | 2026 | 42676633 | PubTator, text mining | PubMed |
| CAD-RADS 2.0-guided diagnostic pathways in chronic coronary syndromes: a real-world Polish registry of over 10 000 patients. | Kardiol Pol | 2026 | 42639957 | PubTator, text mining | PubMed |
| Robust structural, kinetic and biophysical characterization of wild-type human ACOD1, selected mutants and their interaction with citraconate. | J Struct Biol X | 2026 | 42631184 | PubTator, text mining | PubMed |
| ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression. | Pathol Res Pract | 2026 | 42617477 | PubTator, text mining | PubMed |
1 to 10 of 2,030
See all 2,030 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/730249/patents