Gene · 7305
TYROBP: transmembrane immune signaling adaptor TYROBP
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TYROBP: transmembrane immune signaling adaptor TYROBP. Genes, record 7305. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7305
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43914 | TYRO protein tyrosine kinase-binding protein | 113 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents266
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4795154 A1 | 2026-08-26 | 107 | O43914 | Espacenet |
| EP 4774292 A1 | 2026-07-15 | 262 | O43914 | Espacenet |
| EP 4759370 A2 | 2026-06-17 | 9 | O43914 | Espacenet |
| EP 4754241 A1 | 2026-06-10 | 4 | O43914 | Espacenet |
| EP 4752227 A2 | 2026-06-03 | 27 | O43914 | Espacenet |
| EP 4720302 A1 | 2026-04-08 | 7 | O43914 | Espacenet |
| JP 2026054469 A | 2026-03-26 | 43 | O43914 | Espacenet |
| US 12559537 B2 | 2026-02-24 | 46 | O43914 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68765 | O43914 | Espacenet |
| JP 2025185029 A | 2025-12-18 | 354 | O43914 | Espacenet |
1 to 10 of 266
See all 266 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,430
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TYROBP papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 12 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 11 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P01AG026276 | Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study | 10 | 2025 |
| R01AR046713 | Cytokine regulation of RA synoviocyte phenotype | 10 | 2025 |
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 9 | 2025 |
| P01CA111412 | NK cells, their receptors and cancer therapy | 9 | 2025 |
| P30AG066444 | Alzheimer's Disease Research Center | 8 | 2025 |
1 to 10 of 2,430Source NIH's project files
See all 2,430 nih grantsPapers3,266
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Therapeutic Strategies Targeting TREM2 for Alzheimer's Disease: Current Advances and Future Perspectives. | Curr Neuropharmacol | 2026 | 42786847 | PubTator, text mining | PubMed |
| Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India. | Front Immunol | 2026 | 42756106 | PubTator, text mining | PubMed |
| TREM2: A Potential Target for the Targeted Therapy of Metabolic Diseases. | Mediators Inflamm | 2026 | 42714953 | PubTator, text mining | PubMed |
| TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting. | Front Immunol | 2026 | 42694654 | PubTator, text mining | PubMed |
| Multi-omics identification of haptoglobin as a novel target for increased Alzheimer's disease risk associated with obesity through inhibiting the phagocytosis of Aβ by disease-associated microglia. | Alzheimers Dement | 2026 | 42634158 | PubTator, text mining | PubMed |
| Decoding TREM2: A microglial receptor governing the fate of myelin. | Cell Signal | 2026 | 42595239 | PubTator, text mining | PubMed |
| TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies. | Cell Commun Signal | 2026 | 42458498 | PubTator, text mining | PubMed |
| Immunomodulatory Effects of Volatile Anesthetic Sevoflurane on Cardiomyocytes after Coronary Artery Bypass Grafting: Insights from Bioinformatics Analysis. | Iran J Allergy Asthma Immunol | 2026 | 42437319 | PubTator, text mining | PubMed |
| M1 polarization accelerated bone aging through inflammatory signaling transduction regulated by cells crosstalk. | Int Immunopharmacol | 2026 | 42419146 | PubTator, text mining | PubMed |
| In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia-Telangiectasia. | Chem Biol Drug Des | 2026 | 42384606 | PubTator, text mining | PubMed |
1 to 10 of 3,266
See all 3,266 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7305
GET https://conductscience.org/api/genes/v1/7305/patents?page=2