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Gene · 7305

TYROBP: transmembrane immune signaling adaptor TYROBP

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TYROBP: transmembrane immune signaling adaptor TYROBP. Genes, record 7305. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7305

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Gene

Symbol
TYROBP
HGNC
Name
transmembrane immune signaling adaptor TYROBP
HGNC
NCBI Gene ID
7305
NCBI Gene
HGNC ID
HGNC:12449
HGNC
Ensembl
ENSG00000011600
NCBI Gene
Aliases
DAP12, KARAP, PLO-SL, PLOSL, PLOSL1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43914TYRO protein tyrosine kinase-binding protein1135Ensembl, GeneID, HGNC

Source UniProt

Patents266

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26107O43914Espacenet
EP 4774292 A12026-07-15262O43914Espacenet
EP 4759370 A22026-06-179O43914Espacenet
EP 4754241 A12026-06-104O43914Espacenet
EP 4752227 A22026-06-0327O43914Espacenet
EP 4720302 A12026-04-087O43914Espacenet
JP 2026054469 A2026-03-2643O43914Espacenet
US 12559537 B22026-02-2446O43914Espacenet
JP 2026004568 A2026-01-1468765O43914Espacenet
JP 2025185029 A2025-12-18354O43914Espacenet

1 to 10 of 266

See all 266 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,430

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTYROBP papersNewest fiscal year
P30CA008748Cancer Center Support Grant212025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)122025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions112025
P30CA006927Comprehensive Cancer Center Program at Fox Chase112025
P30CA016672Cancer Center Support Grant112025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study102025
R01AR046713Cytokine regulation of RA synoviocyte phenotype102025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies92025
P01CA111412NK cells, their receptors and cancer therapy92025
P30AG066444Alzheimer's Disease Research Center82025

1 to 10 of 2,430Source NIH's project files

See all 2,430 nih grants

Papers3,266

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Therapeutic Strategies Targeting TREM2 for Alzheimer's Disease: Current Advances and Future Perspectives.Curr Neuropharmacol202642786847PubTator, text miningPubMed
Real-world insights into genomic reprogramming during CAR-T cell manufacturing in India.Front Immunol202642756106PubTator, text miningPubMed
TREM2: A Potential Target for the Targeted Therapy of Metabolic Diseases.Mediators Inflamm202642714953PubTator, text miningPubMed
TREM2 as a central hub of neuroimmune-metabolic crosstalk in central nervous system disorders: from microglial biology to therapeutic targeting.Front Immunol202642694654PubTator, text miningPubMed
Multi-omics identification of haptoglobin as a novel target for increased Alzheimer's disease risk associated with obesity through inhibiting the phagocytosis of Aβ by disease-associated microglia.Alzheimers Dement202642634158PubTator, text miningPubMed
Decoding TREM2: A microglial receptor governing the fate of myelin.Cell Signal202642595239PubTator, text miningPubMed
TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell Commun Signal202642458498PubTator, text miningPubMed
Immunomodulatory Effects of Volatile Anesthetic Sevoflurane on Cardiomyocytes after Coronary Artery Bypass Grafting: Insights from Bioinformatics Analysis.Iran J Allergy Asthma Immunol202642437319PubTator, text miningPubMed
M1 polarization accelerated bone aging through inflammatory signaling transduction regulated by cells crosstalk.Int Immunopharmacol202642419146PubTator, text miningPubMed
In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia-Telangiectasia.Chem Biol Drug Des202642384606PubTator, text miningPubMed

1 to 10 of 3,266

See all 3,266 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7305

GET https://conductscience.org/api/genes/v1/7305/patents?page=2