Gene · 7306
TYRP1: tyrosinase related protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TYRP1: tyrosinase related protein 1. Genes, record 7306. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7306
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17643 | 5,6-dihydroxyindole-2-carboxylic acid oxidase | 537 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents53
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025538347 A | 2025-11-28 | 7 | P17643 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10644 | P17643 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11027 | P17643 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13854 | P17643 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5141 | P17643 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7990 | P17643 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5141 | P17643 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7990 | P17643 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11027 | P17643 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10644 | P17643 | Espacenet |
1 to 10 of 53
See all 53 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| FLANVOTUMAB | CHEMBL2108734 | 5,6-dihydroxyindole-2-carboxylic acid oxidase other | OTHER |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT01137006 | FLANVOTUMAB | PHASE1 | 2019-06-17 |
Source ClinicalTrials.gov
NIH grants1,707
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TYRP1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| R01AR043369 | MITF from control of pigmentation to melanoma risk | 18 | 2025 |
| R01EY015625 | Hermansky-Pudlak syndrome and melanosome formation | 17 | 2025 |
| P01CA163222 | Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment | 15 | 2025 |
| ZIAEY000476 | Proteins From Hereditary Eye Diseases: In silico and Experimental Studies | 14 | 2025 |
| ZIAHG000215 | Human Biochemical Genetics | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 7 | 2025 |
| K12GM081259 | IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT). | 6 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 1,707Source NIH's project files
See all 1,707 nih grantsPapers3,635
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A thiosemicarbazone derivative as a potential multi-target inhibitor: Molecular docking, DFT, QTAIM, and NLO investigation of thione and thiol tautomers. | Talanta | 2027 | 42710135 | PubTator, text mining | PubMed |
| Self-assembled micelles of Glycyrrhizic acid and Glabridin: A novel transdermal delivery system with enhanced whitening efficacy. | Int J Pharm | 2026 | 42822710 | PubTator, text mining | PubMed |
| Salt Stress Accelerates Tyrosine Depletion by Enterococcus lactis KUST2812: Multi-Omics Insights into Metabolic Remodeling. | Foods | 2026 | 42793976 | PubTator, text mining | PubMed |
| Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway. | Bioresour Bioprocess | 2026 | 42730979 | PubTator, text mining | PubMed |
| Establishment of Stable Immortalized Human Choroidal Melanocytes for Ocular Research. | Invest Ophthalmol Vis Sci | 2026 | 42720426 | PubTator, text mining | PubMed |
| Computational and Cellular Evaluation of the Anti-Melanogenic Potential of Gancidin W: Integrating Network Pharmacology and Free-Energy Analyses. | Pharmaceuticals (Basel) | 2026 | 42653688 | PubTator, text mining | PubMed |
| CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/β-catenin pathway. | Front Immunol | 2026 | 42601941 | PubTator, text mining | PubMed |
| Exploratory transcriptomic analysis of low-grade oral epithelial dysplasia and oral squamous cell carcinoma in Chilean patients. | Mol Biol Rep | 2026 | 42525276 | PubTator, text mining | PubMed |
| DeepExoMir: A Reproducible RNA Language Model Framework for CLIP-Seq-Supported MicroRNA Target-Site Prioritization. | Int J Mol Sci | 2026 | 42511528 | PubTator, text mining | PubMed |
| A rescue assay for genetic diagnosis of oculocutaneous albinism using melanocytic MNT1 knock-out cells. | Front Genet | 2026 | 42394945 | PubTator, text mining | PubMed |
1 to 10 of 3,635
See all 3,635 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7306
GET https://conductscience.org/api/genes/v1/7306/patents?page=2