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Gene · 7306

TYRP1: tyrosinase related protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TYRP1: tyrosinase related protein 1. Genes, record 7306. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7306

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Gene

Symbol
TYRP1
HGNC
Name
tyrosinase related protein 1
HGNC
NCBI Gene ID
7306
NCBI Gene
HGNC ID
HGNC:12450
HGNC
Ensembl
ENSG00000107165
NCBI Gene
Aliases
CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P176435,6-dihydroxyindole-2-carboxylic acid oxidase53713Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025538347 A2025-11-287P17643Espacenet
EP 4650780 A22025-11-1910644P17643Espacenet
EP 4641201 A22025-10-2911027P17643Espacenet
JP 2025147176 A2025-10-0613854P17643Espacenet
JP 2025529142 A2025-09-045141P17643Espacenet
JP 2025529142 A2025-09-047990P17643Espacenet
US 12371689 B22025-07-295141P17643Espacenet
US 12371689 B22025-07-297990P17643Espacenet
JP 2025517969 A2025-06-1211027P17643Espacenet
JP 2025517970 A2025-06-1210644P17643Espacenet

1 to 10 of 53

See all 53 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
FLANVOTUMABCHEMBL21087345,6-dihydroxyindole-2-carboxylic acid oxidase otherOTHER

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT01137006FLANVOTUMABPHASE12019-06-17

NIH grants1,707

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTYRP1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
R01AR043369MITF from control of pigmentation to melanoma risk182025
R01EY015625Hermansky-Pudlak syndrome and melanosome formation172025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment152025
ZIAEY000476Proteins From Hereditary Eye Diseases: In silico and Experimental Studies142025
ZIAHG000215Human Biochemical Genetics122025
P30CA016672Cancer Center Support Grant102025
P30CA010815Consolidated Basic Cancer Research Program72025
K12GM081259IRACDA at the University of Pennsylvania: Penn Postdoctoral Opportunities in Research and Teaching (PennPORT).62025
P30CA016086Cancer Center Support Grant62025

1 to 10 of 1,707Source NIH's project files

See all 1,707 nih grants

Papers3,635

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A thiosemicarbazone derivative as a potential multi-target inhibitor: Molecular docking, DFT, QTAIM, and NLO investigation of thione and thiol tautomers.Talanta202742710135PubTator, text miningPubMed
Self-assembled micelles of Glycyrrhizic acid and Glabridin: A novel transdermal delivery system with enhanced whitening efficacy.Int J Pharm202642822710PubTator, text miningPubMed
Salt Stress Accelerates Tyrosine Depletion by Enterococcus lactis KUST2812: Multi-Omics Insights into Metabolic Remodeling.Foods202642793976PubTator, text miningPubMed
Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway.Bioresour Bioprocess202642730979PubTator, text miningPubMed
Establishment of Stable Immortalized Human Choroidal Melanocytes for Ocular Research.Invest Ophthalmol Vis Sci202642720426PubTator, text miningPubMed
Computational and Cellular Evaluation of the Anti-Melanogenic Potential of Gancidin W: Integrating Network Pharmacology and Free-Energy Analyses.Pharmaceuticals (Basel)202642653688PubTator, text miningPubMed
CXCL1-CXCR2 axis inhibits melanogenesis through the suppression of the WNT/β-catenin pathway.Front Immunol202642601941PubTator, text miningPubMed
Exploratory transcriptomic analysis of low-grade oral epithelial dysplasia and oral squamous cell carcinoma in Chilean patients.Mol Biol Rep202642525276PubTator, text miningPubMed
DeepExoMir: A Reproducible RNA Language Model Framework for CLIP-Seq-Supported MicroRNA Target-Site Prioritization.Int J Mol Sci202642511528PubTator, text miningPubMed
A rescue assay for genetic diagnosis of oculocutaneous albinism using melanocytic MNT1 knock-out cells.Front Genet202642394945PubTator, text miningPubMed

1 to 10 of 3,635

See all 3,635 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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