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Gene · 7321

UBE2D1: ubiquitin conjugating enzyme E2 D1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UBE2D1: ubiquitin conjugating enzyme E2 D1. Genes, record 7321. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7321

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Gene

Symbol
UBE2D1
HGNC
Name
ubiquitin conjugating enzyme E2 D1
HGNC
NCBI Gene ID
7321
NCBI Gene
HGNC ID
HGNC:12474
HGNC
Ensembl
ENSG00000072401
NCBI Gene
Aliases
E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, UbcH5A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51668Ubiquitin-conjugating enzyme E2 D114714Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026063204 A2026-04-104P51668Espacenet
JP 2026004568 A2026-01-1469057P51668Espacenet
EP 4650780 A22025-11-199397P51668Espacenet
WO 2025125630 A12025-06-19100P51668Espacenet
JP 2025517970 A2025-06-129397P51668Espacenet
EP 4437343 A12024-10-024P51668Espacenet
JP 2023550743 A2023-12-0570P51668Espacenet
JP 2023097901 A2023-07-105P51668Espacenet
JP 2023504790 A2023-02-0714P51668Espacenet
US 11446398 B22022-09-2095125P51668Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,455

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUBE2D1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)132025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control102025
R01HL096376E3 Ligase-Mediated Immunosuppression in Acute Lung Injury92025
R01HL097376Sepsis-Associated Immune Suppression and F-box Proteins92025
P30CA008748Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
P30DK026743UCSF Liver Center82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
R01CA240981Harnessing E3 Ligases for Cancer Therapy62025
R35GM128855Spindle Assembly Checkpoint Silencing52025

1 to 10 of 1,455Source NIH's project files

See all 1,455 nih grants

Papers1,643

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Predictive molecular signatures for successful tapering of canakinumab in systemic juvenile idiopathic arthritis.Ann Rheum Dis202642772990PubTator, text miningPubMed
Fluorophore placement and size impact E2 ubiquitination efficiency.Biochem J202642770861PubTator, text miningPubMed
Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.PLoS One202642412755PubTator, text miningPubMed
Protocol for integrated ubiquitination analysis of in vitro E3 ligase-DUB regulation and in vivo ubiquitin chain linkage characterization.STAR Protoc202642397747PubTator, text miningPubMed
Erratum: IGF2BP2-modified UBE2D1 Interacts with Smad2/3 to Promote the Progression of Breast Cancer.Am J Cancer Res202642266759PubTator, text miningPubMed
CD14+CXCL10+ monocytes are associated with peripheral immune network alterations in systemic juvenile idiopathic arthritis: From multiple centers.Genes Dis202642004226PubTator, text miningPubMed
Liquid-liquid phase separation couples MKRN2-mediated ubiquitination of CSDE1 with neurodevelopmental disorders.Front Cell Neurosci202641757349PubTator, text miningPubMed
High UBE2D1 expression is associated with poor prognosis and immunotherapy resistance in head and neck cancer.J Oral Biol Craniofac Res202641732664PubTator, text miningPubMed
Structure-guided analysis and prediction of human E2-E3 ligase pairing specificity.bioRxiv202641726935PubTator, text miningPubMed
Emerging biologic modalities for targeted protein degradation.J Biol Chem202641651431PubTator, text miningPubMed

1 to 10 of 1,643

See all 1,643 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7321

GET https://conductscience.org/api/genes/v1/7321/patents?page=2