ConductScience.org, home

Gene · 7334

UBE2N: ubiquitin conjugating enzyme E2 N

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. UBE2N: ubiquitin conjugating enzyme E2 N. Genes, record 7334. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7334

On this page

Gene

Symbol
UBE2N
HGNC
Name
ubiquitin conjugating enzyme E2 N
HGNC
NCBI Gene ID
7334
NCBI Gene
HGNC ID
HGNC:12492
HGNC
Ensembl
ENSG00000177889
NCBI Gene
Aliases
HEL-S-71, MGC8489, UBC13, UBCHBEN, UBCHBEN; UBC13, UbcH-ben, UbcH13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61088Ubiquitin-conjugating enzyme E2 N15244Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195053P61088Espacenet
JP 2025517970 A2025-06-125053P61088Espacenet
US 11976334 B22024-05-07212P61088Espacenet
JP 2023550743 A2023-12-0588P61088Espacenet
US 11564998 B22023-01-315398P61088Espacenet
US 11446398 B22022-09-2095253P61088Espacenet
JP 2022524081 A2022-04-27198224P61088Espacenet
US 11078247 B22021-08-0312239P61088Espacenet
JP 2020508335 A2020-03-19212P61088Espacenet
WO 2020043864 A12020-03-052730P61088Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,718

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUBE2N papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
R01GM065334Solution structure and dynamics of polyubiquitin chains102025
P01CA092584Structural Cell Biology of DNA Repair Machines82025
P30CA021765Cancer Center Support Grant (CCSG)72025
P30CA008748Cancer Center Support Grant62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
R01AI127465Effector-mediated ubiquitin manipulation in Legionella pneumophila pathogenesis62025
P30CA016086Cancer Center Support Grant42025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA054174Mays Cancer Center at UT Health SA42025

1 to 10 of 1,718Source NIH's project files

See all 1,718 nih grants

Papers2,223

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.Diagnostics (Basel)202642793752PubTator, text miningPubMed
Fluorophore placement and size impact E2 ubiquitination efficiency.Biochem J202642770861PubTator, text miningPubMed
UBE2N flips the switch on for mitophagy and off for MASH.Nat Metab202642698002PubTator, text miningPubMed
UBE2N deficiency contributes to MASH development via p62-regulated mitophagy and PANoptosis.Nat Metab202642698001PubTator, text miningPubMed
Small-molecule disruption of the TRAF6-Ubc13 protein-protein interaction: targeting noncanonical ubiquitin signaling in inflammation and cancer.Biochem Pharmacol202642660298PubTator, text miningPubMed
Inhibition of UBE2N enhances TRAIL-mediated apoptosis through upregulation of DR5 in cancer cells.Int J Med Sci202642524317PubTator, text miningPubMed
Ubiquitin-Derived Diglycine Remnants as Chemical Handles for Chemoenzymatic Proteomics.bioRxiv202642427753PubTator, text miningPubMed
Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.PLoS One202642412755PubTator, text miningPubMed
BRD4-mediated histone H4K12 lactylation drives ovarian cancer progression by activating the Ube2v1-DDX3X ubiquitination axis.J Transl Med202642374413PubTator, text miningPubMed
Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.Biochem Med (Zagreb)202642299353PubTator, text miningPubMed

1 to 10 of 2,223

See all 2,223 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7334

GET https://conductscience.org/api/genes/v1/7334/patents?page=2