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UCP1: uncoupling protein 1

1 protein, 73 patents, 0 drugs, 0 trials, 3,620 NIH grants and 9,106 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolUCP1HGNC
Nameuncoupling protein 1HGNC
NCBI Gene ID7350NCBI Gene
HGNC IDHGNC:12517HGNC
EnsemblENSG00000109424NCBI Gene
AliasesSLC25A7, UCPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25874Mitochondrial brown fat uncoupling protein 13078Ensembl, GeneID, HGNCUniProt

Patents 73

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11504P25874Espacenet
JP 2026004568 A2026-01-1469302P25874Espacenet
WO 2025227129 A22025-10-3046P25874Espacenet
EP 4620519 A22025-09-241P25874Espacenet
EP 4620520 A22025-09-241P25874Espacenet
EP 4620521 A22025-09-241P25874Espacenet
JP 2025529142 A2025-09-045157P25874Espacenet
US 12371689 B22025-07-295157P25874Espacenet
JP 2025013347 A2025-01-24162P25874Espacenet
JP 2025013347 A2025-01-24504P25874Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3620

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK036836Diabetes Research Center562,025NIH's project files
P30DK072476Pennington/Louisiana NORC492,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)482,025NIH's project files
R01DK097441Molecular mechanisms of UCP1-independent pathways in metabolic health432,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)262,025NIH's project files
P30DK020579Diabetes Research Center232,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center232,025NIH's project files
T32DK007260Training Grant in Diabetes and Metabolism202,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)172,025NIH's project files
R01DK082659Developmental genes, miRNAs and adipose tissue172,025NIH's project files

Papers 9106

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42800535PubTator, text miningPubMed
42743079PubTator, text miningPubMed
42731027PubTator, text miningPubMed
42727167PubTator, text miningPubMed
42722870PubTator, text miningPubMed
42699776PubTator, text miningPubMed
42694970PubTator, text miningPubMed
42692239PubTator, text miningPubMed
42660416PubTator, text miningPubMed
42606522PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license