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Gene · 7357

UGCG: UDP-glucose ceramide glucosyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UGCG: UDP-glucose ceramide glucosyltransferase. Genes, record 7357. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7357

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Gene

Symbol
UGCG
HGNC
Name
UDP-glucose ceramide glucosyltransferase
HGNC
NCBI Gene ID
7357
NCBI Gene
HGNC ID
HGNC:12524
HGNC
Ensembl
ENSG00000148154
NCBI Gene
Aliases
GCS, GLCT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16739Ceramide glucosyltransferase3940Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026510807 A2026-04-106Q16739Espacenet
JP 2026004568 A2026-01-1469201Q16739Espacenet
EP 4650780 A22025-11-199445Q16739Espacenet
KR 1020250159168 A2025-11-106Q16739Espacenet
JP 2025529142 A2025-09-045158Q16739Espacenet
US 12371689 B22025-07-295158Q16739Espacenet
KR 1020250103878 A2025-07-082Q16739Espacenet
JP 2025517970 A2025-06-129445Q16739Espacenet
WO 2025093745 A12025-05-08327Q16739Espacenet
US 11446398 B22022-09-2095582Q16739Espacenet

1 to 10 of 52

See all 52 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ELIGLUSTATCHEMBL2110588Ceramide glucosyltransferase inhibitorINHIBITORChEMBL
ELIGLUSTAT TARTRATECHEMBL5723563Ceramide glucosyltransferase inhibitorINHIBITORChEMBL
LUCERASTATCHEMBL1086997Ceramide glucosyltransferase inhibitorINHIBITORChEMBL
MIGLUSTATCHEMBL1029Ceramide glucosyltransferase inhibitorINHIBITORChEMBL
VENGLUSTATCHEMBL4297611Ceramide glucosyltransferase inhibitorINHIBITORChEMBL

Trials54

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07399704MIGLUSTATPHASE2ClinicalTrials.gov
NCT07138547ELIGLUSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07090538ELIGLUSTATEARLY_PHASE1ClinicalTrials.gov
NCT06558773ELIGLUSTATPHASE2ClinicalTrials.gov
NCT06523517ELIGLUSTATPHASE2ClinicalTrials.gov
NCT05280548VENGLUSTATPHASE3ClinicalTrials.gov
NCT05222906VENGLUSTATPHASE3ClinicalTrials.gov
NCT05206773VENGLUSTATPHASE3ClinicalTrials.gov
NCT05174039MIGLUSTATPHASE1/PHASE22025-09-09ClinicalTrials.gov
NCT04944888ELIGLUSTATPHASE1ClinicalTrials.gov

1 to 10 of 54

See all 54 trials

NIH grants1,076

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUGCG papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy282025
P20GM103424Louisiana Biomedical Research Network102025
ZIAHG200336Genetic and clinical studies of Gaucher disease and other lysosomal disorders92025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant82025
UL1TR001863Yale Clinical and Translational Science Award82025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy72025
P30MH075673JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)62025
R01HL103411Systems Biology of Glycosylation62025
P30CA008748Cancer Center Support Grant52025
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays52025

1 to 10 of 1,076Source NIH's project files

See all 1,076 nih grants

Papers2,116

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glucosylceramide synthase is required for C6-ceramide nanoliposome-induced organelle stress and cell death.bioRxiv202642818015PubTator, text miningPubMed
Machine Learning-Guided Multi-Omics Integration Identifies UGCG as a Candidate Lipid Metabolic Biomarker and Potential Therapeutic Target in Sepsis.J Inflamm Res202642808034PubTator, text miningPubMed
Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.Adv Sci (Weinh)202642801631PubTator, text miningPubMed
Miglustat in Neuronopathic Lysosomal Storage Disorders: Biological Rationale, Clinical Evidence, and Limits of Repurposing.Int J Mol Sci202642794762PubTator, text miningPubMed
Measles virus reprograms CD4+ T-cell sphingolipid and fatty acid metabolism to facilitate infection.Front Cell Dev Biol202642688487PubTator, text miningPubMed
A 16 × 8 Focused Compound Library Comprising All Configurational Isomers of the Archetypal Iminosugar, 1-Deoxynojirimycin.J Med Chem202642679158PubTator, text miningPubMed
Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG.Nature202642649293PubTator, text miningPubMed
Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion.Transl Stroke Res202642625084PubTator, text miningPubMed
Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses.J Gen Virol202642593847PubTator, text miningPubMed
Integrated Multi-Omics Analysis Uncovers Molecular Dysregulation in Glucosylceramide Synthase-Deficient Human Induced Pluripotent Stem Cells.Mol Cell Proteomics202642492790PubTator, text miningPubMed

1 to 10 of 2,116

See all 2,116 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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