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Gene · 7372

UMPS: uridine monophosphate synthetase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UMPS: uridine monophosphate synthetase. Genes, record 7372. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7372

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Gene

Symbol
UMPS
HGNC
Name
uridine monophosphate synthetase
HGNC
NCBI Gene ID
7372
NCBI Gene
HGNC ID
HGNC:12563
HGNC
Ensembl
ENSG00000114491
NCBI Gene
Aliases
ODC, OPRT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P11172Uridine 5'-monophosphate synthase480112Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21182P11172Espacenet
JP 2026004568 A2026-01-1469349P11172Espacenet
EP 4650780 A22025-11-19829P11172Espacenet
JP 2025517970 A2025-06-12829P11172Espacenet
JP 2023521663 A2023-05-25181P11172Espacenet
US 11446398 B22022-09-2095911P11172Espacenet
JP 2022532535 A2022-07-1531P11172Espacenet
JP 2022524081 A2022-04-27198882P11172Espacenet
KR 1020220018495 A2022-02-153P11172Espacenet
JP 2021530985 A2021-11-18289P11172Espacenet

1 to 10 of 52

See all 52 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
AZARIBINECHEMBL515914Uridine 5'-monophosphate synthase inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants700

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUMPS papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)72025
R35GM134881Studies on Enzyme Activation52025
P30CA016672Cancer Center Support Grant42025
P30CA012197Cancer Center Support Grant32025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer32025
P30CA008748Cancer Center Support Grant22025
P30CA013148Comprehensive Cancer Center Support Grant22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025

1 to 10 of 700Source NIH's project files

See all 700 nih grants

Papers1,811

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity.Cell Rep202642334921PubTator, text miningPubMed
Lentiviral rescue of UMPS auxotrophy enables drug-free selection and stable vector expression.Mol Ther Adv202642290941PubTator, text miningPubMed
Design, Synthesis, and Biological Evaluation of Novel Quinazoline-Thiazole Hybrids As Potential Anticancer Agents.J Biochem Mol Toxicol202642231635PubTator, text miningPubMed
The oncogenic control of nucleotide synthesis.Oncogenesis202641881963PubTator, text miningPubMed
Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors.iScience202641767257PubTator, text miningPubMed
The visualizable and marker-free gene editing platform mediated by CRISPR/Cas9 in Coleophoma empetri.Appl Microbiol Biotechnol202641741688PubTator, text miningPubMed
Acute Gout Flare After Carboplatin/5-Fluorouracil for Locally Advanced Head and Neck Squamous Cell Carcinoma.Cancer Rep (Hoboken)202641718452PubTator, text miningPubMed
Loss of BOK increases vulnerability of p53 deficient non-small cell lung cancer cells to ATR inhibition through its role in uridine metabolism.Cell Death Differ202641611842PubTator, text miningPubMed
BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia.Ann Hematol202641549155PubTator, text miningPubMed
Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review.Biochem Soc Trans202641527724PubTator, text miningPubMed

1 to 10 of 1,811

See all 1,811 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7372

GET https://conductscience.org/api/genes/v1/7372/patents?page=2