Gene · 7372
UMPS: uridine monophosphate synthetase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. UMPS: uridine monophosphate synthetase. Genes, record 7372. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7372
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P11172 | Uridine 5'-monophosphate synthase | 480 | 112 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 182 | P11172 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69349 | P11172 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 829 | P11172 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 829 | P11172 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 181 | P11172 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95911 | P11172 | Espacenet |
| JP 2022532535 A | 2022-07-15 | 31 | P11172 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 198882 | P11172 | Espacenet |
| KR 1020220018495 A | 2022-02-15 | 3 | P11172 | Espacenet |
| JP 2021530985 A | 2021-11-18 | 289 | P11172 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| AZARIBINE | CHEMBL515914 | Uridine 5'-monophosphate synthase inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants700
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | UMPS papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| R35GM134881 | Studies on Enzyme Activation | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 3 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 700Source NIH's project files
See all 700 nih grantsPapers1,811
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity. | Cell Rep | 2026 | 42334921 | PubTator, text mining | PubMed |
| Lentiviral rescue of UMPS auxotrophy enables drug-free selection and stable vector expression. | Mol Ther Adv | 2026 | 42290941 | PubTator, text mining | PubMed |
| Design, Synthesis, and Biological Evaluation of Novel Quinazoline-Thiazole Hybrids As Potential Anticancer Agents. | J Biochem Mol Toxicol | 2026 | 42231635 | PubTator, text mining | PubMed |
| The oncogenic control of nucleotide synthesis. | Oncogenesis | 2026 | 41881963 | PubTator, text mining | PubMed |
| Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors. | iScience | 2026 | 41767257 | PubTator, text mining | PubMed |
| The visualizable and marker-free gene editing platform mediated by CRISPR/Cas9 in Coleophoma empetri. | Appl Microbiol Biotechnol | 2026 | 41741688 | PubTator, text mining | PubMed |
| Acute Gout Flare After Carboplatin/5-Fluorouracil for Locally Advanced Head and Neck Squamous Cell Carcinoma. | Cancer Rep (Hoboken) | 2026 | 41718452 | PubTator, text mining | PubMed |
| Loss of BOK increases vulnerability of p53 deficient non-small cell lung cancer cells to ATR inhibition through its role in uridine metabolism. | Cell Death Differ | 2026 | 41611842 | PubTator, text mining | PubMed |
| BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia. | Ann Hematol | 2026 | 41549155 | PubTator, text mining | PubMed |
| Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review. | Biochem Soc Trans | 2026 | 41527724 | PubTator, text mining | PubMed |
1 to 10 of 1,811
See all 1,811 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7372
GET https://conductscience.org/api/genes/v1/7372/patents?page=2