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Gene · 7376

NR1H2: nuclear receptor subfamily 1 group H member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NR1H2: nuclear receptor subfamily 1 group H member 2. Genes, record 7376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7376

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Gene

Symbol
NR1H2
HGNC
Name
nuclear receptor subfamily 1 group H member 2
HGNC
NCBI Gene ID
7376
NCBI Gene
HGNC ID
HGNC:7965
HGNC
Ensembl
ENSG00000131408
NCBI Gene
Aliases
LXR-b, LXRB, LXRb, NER, NER-I, RIP15, UNR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55055Oxysterols receptor LXR-beta46025Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456142P55055Espacenet
EP 4650780 A22025-11-191466P55055Espacenet
EP 4641201 A22025-10-291081P55055Espacenet
JP 2025147176 A2025-10-0615417P55055Espacenet
JP 2025517969 A2025-06-121081P55055Espacenet
JP 2025517970 A2025-06-121466P55055Espacenet
JP 2025028160 A2025-02-2815417P55055Espacenet
KR 1020250010750 A2025-01-2115417P55055Espacenet
JP 2024109657 A2024-08-1415256P55055Espacenet
US 11446398 B22022-09-2058385P55055Espacenet

1 to 10 of 32

See all 32 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEQUOLIXRONCHEMBL573677Liver X receptor agonistAGONISTChEMBL
BMS-779788CHEMBL3360975LXR-beta agonistAGONISTChEMBL
BMS-852927CHEMBL3945199LXR-beta modulatorMODULATORChEMBL
CS-8080CHEMBL3545238LXR-beta agonistAGONISTChEMBL
HYODEOXYCHOLIC_ACIDCHEMBL272621LXR-beta agonistAGONISTChEMBL
LXR-623CHEMBL456237LXR-beta agonistAGONISTChEMBL
ROVAZOLACCHEMBL4297218Liver X receptor agonistAGONISTChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05911308ABEQUOLIXRONPHASE1ClinicalTrials.gov
NCT03859986ROVAZOLACPHASE2ClinicalTrials.gov
NCT03175354ROVAZOLACPHASE2ClinicalTrials.gov
NCT02922764ABEQUOLIXRONPHASE1ClinicalTrials.gov
NCT01931241HYODEOXYCHOLIC_ACIDPHASE1ClinicalTrials.gov
NCT01651273BMS-852927PHASE1ClinicalTrials.gov

NIH grants1,123

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNR1H2 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)92025
P30CA008748Cancer Center Support Grant82025
P30EY005722Center Core Grant for Vision Research72025
ZIAES101586Nuclear receptors: action, functions, and roles in disease52025
P30CA016672Cancer Center Support Grant42025
P30CA086862Cancer Center Support Grant42025
I01BX004293CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer32025
P30CA016042Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30DK048520Colorado Nutrition Obesity Research Center32025

1 to 10 of 1,123Source NIH's project files

See all 1,123 nih grants

Papers1,865

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Context-dependent regulation of cytotoxic T lymphocytes by nuclear receptors.J Immunol202642823066PubTator, text miningPubMed
Docosahexaenoic Acid Enhances the Cytotoxic Effects of Enzalutamide and the PARP Inhibitor in Castration-Resistant Prostate Cancer Cell Lines.Int J Mol Sci202642794467PubTator, text miningPubMed
Artificial intelligence-guided discovery of fungal ergosterol derivatives as selective LXRβ agonists targeting the cholesterol dependency of glioblastoma.Mol Divers202642732035PubTator, text miningPubMed
The unfolded protein sensor IRE1 is essential for homeostatic dendritic cell maturation.Nat Commun202642463662PubTator, text miningPubMed
Targeting USP8 with odoroside A regulates LXRβ-mediated fatty acid metabolic reprogramming against colorectal cancer.Acta Pharmacol Sin202642420594PubTator, text miningPubMed
Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers.Elife202642325211PubTator, text miningPubMed
5,6-epoxycholestanols metabolism and functions: Defining the epoxycholestanoid (EChA) family.Prog Lipid Res202642202938PubTator, text miningPubMed
Carbamate and Sulfamate Bioisosteres of N,N-Dimethyl-3β-Hydroxycholenamide as Ligands of the Liver X Receptors.Chempluschem202642043883PubTator, text miningPubMed
MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes.Nat Commun202641963318PubTator, text miningPubMed
TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease.Alzheimers Dement202641954048PubTator, text miningPubMed

1 to 10 of 1,865

See all 1,865 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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