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Gene · 7378

UPP1: uridine phosphorylase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UPP1: uridine phosphorylase 1. Genes, record 7378. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7378

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Gene

Symbol
UPP1
HGNC
Name
uridine phosphorylase 1
HGNC
NCBI Gene ID
7378
NCBI Gene
HGNC ID
HGNC:12576
HGNC
Ensembl
ENSG00000183696
NCBI Gene
Aliases
UDRPASE, UP, UPASE, UPP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16831Uridine phosphorylase 13103Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469353Q16831Espacenet
JP 2026004568 A2026-01-1469354Q16831Espacenet
JP 2026004568 A2026-01-1469355Q16831Espacenet
EP 4650780 A22025-11-195836Q16831Espacenet
EP 4641201 A22025-10-295549Q16831Espacenet
JP 2025517969 A2025-06-125549Q16831Espacenet
JP 2025517970 A2025-06-125836Q16831Espacenet
JP 2025032204 A2025-03-1138002Q16831Espacenet
JP 2025032204 A2025-03-1138006Q16831Espacenet
EP 4461818 A22024-11-1338002Q16831Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants976

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUPP1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant62025
P30CA016087Cancer Center Support Grant32025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK056338Texas Medical Center Digestive Diseases Center32025
P50CA058223SPORE in Breast Cancer32025
R01GM098535Molecular mechanisms of DNA damage signaling and repair32025
T32CA067754Cancer Biology, Informatics & Omics (CBIO) Training Program32025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment22025

1 to 10 of 976Source NIH's project files

See all 976 nih grants

Papers1,570

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical evaluation of a novel urinary protein competitive immunoassay in the detection of proteinuria in adults with sickle cell disease.Front Med (Lausanne)202642745797PubTator, text miningPubMed
UPP1 as a Diagnostic Biomarker: Insights from Integrative Bioinformatics and Immune Infiltration Analyses in COPD.J Vis Exp202642695583PubTator, text miningPubMed
UPP1 in Cancer: Context-Dependent Roles in Metabolic Adaptation and Treatment Response.Curr Issues Mol Biol202642651811PubTator, text miningPubMed
Integration of RNA-seq and scRNA-seq to investigate the role of cell cycle-related biomarkers in sepsis.PLoS One202642579704PubTator, text miningPubMed
Comparative Analysis of LPS/IFN-γ and LPS/ATP-Induced Inflammatory Models in BV2 Microglia.Neurochem Res202642566061PubTator, text miningPubMed
Targeted Transcriptomic Profiling Identifies Biomarkers and Molecular Features Associated With Immunotherapy Response in Classic Hodgkin Lymphoma.Mod Pathol202642556471PubTator, text miningPubMed
Concordant RNA-protein evidence and human tissue metabolomics prioritize UPP1-associated nucleotide remodeling in prostate cancer.PLoS One202642536695PubTator, text miningPubMed
Enhanced oral absorption and anti-colorectal cancer efficacy of trifluridine by interfering with both TPase and UPase.Bioorg Chem202642424926PubTator, text miningPubMed
Integrative Single-Cell and Bulk Transcriptome Analysis Reveals Molecular Mechanisms, Prognostic Signatures, and Therapeutic Response in Glioma.J Craniofac Surg202642412600PubTator, text miningPubMed
Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis.Cell Death Discov202642409780PubTator, text miningPubMed

1 to 10 of 1,570

See all 1,570 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7378

GET https://conductscience.org/api/genes/v1/7378/patents?page=2