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Gene · 7391

USF1: upstream transcription factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USF1: upstream transcription factor 1. Genes, record 7391. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7391

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Gene

Symbol
USF1
HGNC
Name
upstream transcription factor 1
HGNC
NCBI Gene ID
7391
NCBI Gene
HGNC ID
HGNC:12593
HGNC
Ensembl
ENSG00000158773
NCBI Gene
Aliases
FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22415Upstream stimulatory factor 13101Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469343P22415Espacenet
JP 2026004568 A2026-01-1469344P22415Espacenet
EP 4650780 A22025-11-198347P22415Espacenet
JP 2025147176 A2025-10-0615825P22415Espacenet
JP 2025517970 A2025-06-128347P22415Espacenet
JP 2025028160 A2025-02-2815825P22415Espacenet
KR 1020250010750 A2025-01-2115825P22415Espacenet
JP 2024109657 A2024-08-1415664P22415Espacenet
US 11446398 B22022-09-2095864P22415Espacenet
US 11446398 B22022-09-2095865P22415Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,889

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSF1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis62025
P30CA008748Cancer Center Support Grant52025
P30CA013696Cancer Center Support Grant52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA014051Cancer Center Support (Core) Grant42025
P30CA016058Cancer Center Support Grant42025
P30CA033572Cancer Center Support Grant42025
P30CA036727Buffett Cancer Center Support Grant42025
P30CA042014Cancer Center Support Grant42025

1 to 10 of 1,889Source NIH's project files

See all 1,889 nih grants

Papers2,490

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Seven Homologous Regions from a Novel Bombyx mori Nucleopolyhedrovirus (YT Strain) Isolate Enhance Early and Late Viral Promoters In Vitro and In Vivo.Insects202642652436PubTator, text miningPubMed
Proteome-wide Multi-omics Profiling of Osteosarcoma Transcription Factor Networks.J Mol Biol202642526587PubTator, text miningPubMed
USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders.Funct Integr Genomics202642521865PubTator, text miningPubMed
HLA class I-naturally presented synovial tissue peptides are recognized by CD8+ T lymphocytes from rheumatoid arthritis patients.Front Immunol202642490907PubTator, text miningPubMed
Dibromoacetic acid impairs spermatogenesis: integrative evidence from human epidemiology, network toxicology, and mechanistic validation.Environ Int202642468183PubTator, text miningPubMed
EFO2 promotes triple-negative breast cancer progression and reduces CD8+ T cell-mediated killing by acetylating USF1 to enhance SLC2A1-mediated glycolysis.Biochem Pharmacol202642456828PubTator, text miningPubMed
Arsenic trioxide triggers ferroptosis in neuroblastoma via USF1/GPX4 axis.Bioorg Chem202642322906PubTator, text miningPubMed
LncRNA MIR4435-2HG-mediated succinylation of USF1 promotes its protein stability and induces epithelial-mesenchymal transition in HNSCC.Epigenetics202642132011PubTator, text miningPubMed
Hydrogen-Bond-Directed Assembly of Urea Derivatives: Exceptional Birefringence Achieved by π-Conjugated Unit Alignment.Small202641979121PubTator, text miningPubMed
USF1 transcriptionally activates TRIM55 to promote diabetic cardiomyopathy progression by enhancing HSPB1 protein degradation.J Bioenerg Biomembr202641961164PubTator, text miningPubMed

1 to 10 of 2,490

See all 2,490 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7391

GET https://conductscience.org/api/genes/v1/7391/patents?page=2