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Gene · 7398

USP1: ubiquitin specific peptidase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USP1: ubiquitin specific peptidase 1. Genes, record 7398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7398

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Gene

Symbol
USP1
HGNC
Name
ubiquitin specific peptidase 1
HGNC
NCBI Gene ID
7398
NCBI Gene
HGNC ID
HGNC:12607
HGNC
Ensembl
ENSG00000162607
NCBI Gene
Aliases
UBP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94782Ubiquitin carboxyl-terminal hydrolase 178515Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468961O94782Espacenet
JP 2026004568 A2026-01-1468962O94782Espacenet
EP 4650780 A22025-11-196818O94782Espacenet
EP 4641201 A22025-10-296621O94782Espacenet
JP 2025533524 A2025-10-071O94782Espacenet
EP 4590297 A22025-07-301O94782Espacenet
JP 2025517969 A2025-06-126621O94782Espacenet
JP 2025517970 A2025-06-126818O94782Espacenet
JP 2025511858 A2025-04-161O94782Espacenet
EP 4504175 A12025-02-121O94782Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,019

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP1 papersNewest fiscal year
R01HL052725Molecular Pathogenesis of Fanconi Anemia172025
P01CA092584Structural Cell Biology of DNA Repair Machines132025
P30CA016672Cancer Center Support Grant112025
R01CA168635Mechanistic Dissection of the BRCA1-SETX-dependent Pathway of R-loop Avoidance and Genome Maintenance62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
P30CA016086Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30CA015704Cancer Center Support Grant32025
P30CA086862Cancer Center Support Grant32025
R01CA237263DNA replication stress in cancer32025

1 to 10 of 1,019Source NIH's project files

See all 1,019 nih grants

Papers1,534

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of TRAF1 as a crucial regulator of inflammatory and oxidative injury in acute myocardial infarction.Pathol Res Pract202642731176PubTator, text miningPubMed
Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.Drug Discov Today202642727625PubTator, text miningPubMed
Optimization of a Series of Novel 1H-Pyrrolo[3,2-c]pyridine-Based USP1 Inhibitors with Potent In Vivo Antitumor Activity.J Med Chem202642720480PubTator, text miningPubMed
Exploiting DNA damage tolerance for precision oncology.Trends Cancer202642697814PubTator, text miningPubMed
Weighted Gene Co-Expression Network Analysis and Machine Learning Reveal that USP1 Drives Lipid Metabolism and Macrophage Polarization in Cervical Cancer Cells.Reprod Sci202642638028PubTator, text miningPubMed
USP1 Promotes Malignant Progression of Cervical Cancer Cells by Deubiquitinating and Stabilizing ATG13 to Enhance Autophagic Activity.J Biochem Mol Toxicol202642573051PubTator, text miningPubMed
Serum USP1 and PD-L1 levels independently predict treatment response and prognosis in cervical cancer: a retrospective cohort study.Am J Cancer Res202642465007PubTator, text miningPubMed
FANCI: from genome guardian to translational therapeutic target.Front Oncol202642444811PubTator, text miningPubMed
G quadruplex DNA facilitates a pervasive path to homologous recombination.bioRxiv202642282655PubTator, text miningPubMed
USP1-mediated lipophagy-lipogenesis axis drives cholangiocarcinoma progression and immune evasion.J Immunother Cancer202642259603PubTator, text miningPubMed

1 to 10 of 1,534

See all 1,534 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7398

GET https://conductscience.org/api/genes/v1/7398/patents?page=2