Gene · 7398
USP1: ubiquitin specific peptidase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. USP1: ubiquitin specific peptidase 1. Genes, record 7398. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7398
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | 785 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents73
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68961 | O94782 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68962 | O94782 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6818 | O94782 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6621 | O94782 | Espacenet |
| JP 2025533524 A | 2025-10-07 | 1 | O94782 | Espacenet |
| EP 4590297 A2 | 2025-07-30 | 1 | O94782 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6621 | O94782 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6818 | O94782 | Espacenet |
| JP 2025511858 A | 2025-04-16 | 1 | O94782 | Espacenet |
| EP 4504175 A1 | 2025-02-12 | 1 | O94782 | Espacenet |
1 to 10 of 73
See all 73 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,019
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | USP1 papers | Newest fiscal year |
|---|---|---|---|
| R01HL052725 | Molecular Pathogenesis of Fanconi Anemia | 17 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| R01CA168635 | Mechanistic Dissection of the BRCA1-SETX-dependent Pathway of R-loop Avoidance and Genome Maintenance | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| R01CA237263 | DNA replication stress in cancer | 3 | 2025 |
1 to 10 of 1,019Source NIH's project files
See all 1,019 nih grantsPapers1,534
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of TRAF1 as a crucial regulator of inflammatory and oxidative injury in acute myocardial infarction. | Pathol Res Pract | 2026 | 42731176 | PubTator, text mining | PubMed |
| Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation. | Drug Discov Today | 2026 | 42727625 | PubTator, text mining | PubMed |
| Optimization of a Series of Novel 1H-Pyrrolo[3,2-c]pyridine-Based USP1 Inhibitors with Potent In Vivo Antitumor Activity. | J Med Chem | 2026 | 42720480 | PubTator, text mining | PubMed |
| Exploiting DNA damage tolerance for precision oncology. | Trends Cancer | 2026 | 42697814 | PubTator, text mining | PubMed |
| Weighted Gene Co-Expression Network Analysis and Machine Learning Reveal that USP1 Drives Lipid Metabolism and Macrophage Polarization in Cervical Cancer Cells. | Reprod Sci | 2026 | 42638028 | PubTator, text mining | PubMed |
| USP1 Promotes Malignant Progression of Cervical Cancer Cells by Deubiquitinating and Stabilizing ATG13 to Enhance Autophagic Activity. | J Biochem Mol Toxicol | 2026 | 42573051 | PubTator, text mining | PubMed |
| Serum USP1 and PD-L1 levels independently predict treatment response and prognosis in cervical cancer: a retrospective cohort study. | Am J Cancer Res | 2026 | 42465007 | PubTator, text mining | PubMed |
| FANCI: from genome guardian to translational therapeutic target. | Front Oncol | 2026 | 42444811 | PubTator, text mining | PubMed |
| G quadruplex DNA facilitates a pervasive path to homologous recombination. | bioRxiv | 2026 | 42282655 | PubTator, text mining | PubMed |
| USP1-mediated lipophagy-lipogenesis axis drives cholangiocarcinoma progression and immune evasion. | J Immunother Cancer | 2026 | 42259603 | PubTator, text mining | PubMed |
1 to 10 of 1,534
See all 1,534 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7398
GET https://conductscience.org/api/genes/v1/7398/patents?page=2