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KDM6A: lysine demethylase 6A

1 protein, 39 patents, 0 drugs, 0 trials, 3,071 NIH grants and 4,657 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKDM6AHGNC
Namelysine demethylase 6AHGNC
NCBI Gene ID7403NCBI Gene
HGNC IDHGNC:12637HGNC
EnsemblENSG00000147050NCBI Gene
AliasesKABUK2, UTX, bA386N14.2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15550Lysine-specific demethylase 6A1,4015Ensembl, GeneID, HGNCUniProt

Patents 39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452107O15550Espacenet
EP 4641201 A22025-10-2910262O15550Espacenet
JP 2025147176 A2025-10-067422O15550Espacenet
JP 2025529142 A2025-09-046806O15550Espacenet
US 12371689 B22025-07-296806O15550Espacenet
JP 2025517969 A2025-06-1210262O15550Espacenet
EP 4518908 A22025-03-1212O15550Espacenet
JP 2025028160 A2025-02-287422O15550Espacenet
KR 1020250010750 A2025-01-217422O15550Espacenet
US 12178854 B22024-12-315O15550Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3071

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1022,025NIH's project files
P30CA016672Cancer Center Support Grant462,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)192,025NIH's project files
ZIADK075003Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors152,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase142,025NIH's project files
R35CA197569Mutations of Chromatin and its Modifying Machineries in Malignancies132,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files
P30CA016086Cancer Center Support Grant122,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center122,025NIH's project files
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma122,025NIH's project files

Papers 4657

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42792941PubTator, text miningPubMed
42751076PubTator, text miningPubMed
42715378PubTator, text miningPubMed
42697963PubTator, text miningPubMed
42636791PubTator, text miningPubMed
42615885PubTator, text miningPubMed
42598026PubTator, text miningPubMed
42597942PubTator, text miningPubMed
42567521PubTator, text miningPubMed
42512413PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license