Gene · 7409
VAV1: vav guanine nucleotide exchange factor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. VAV1: vav guanine nucleotide exchange factor 1. Genes, record 7409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7409
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P15498 | Proto-oncogene vav | 845 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 69600 | P15498 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69603 | P15498 | Espacenet |
| EP 4661970 A1 | 2025-12-17 | 62169 | P15498 | Espacenet |
| EP 4661970 A1 | 2025-12-17 | 62176 | P15498 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22363 | P15498 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16606 | P15498 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22363 | P15498 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 16606 | P15498 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 16606 | P15498 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 16445 | P15498 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,874
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | VAV1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 28 | 2025 |
| ZIABC010304 | Biochemical Basis of T Cell Activation | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| P01AI091580 | Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR | 8 | 2025 |
| ZICBC010978 | Confocal Core for the Laboratory of Cellular and Molecular Biology | 8 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 7 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 7 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 7 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 7 | 2025 |
1 to 10 of 2,874Source NIH's project files
See all 2,874 nih grantsPapers3,486
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis. | Int J Genomics | 2026 | 42807562 | PubTator, text mining | PubMed |
| An Increased Circular RNA, circRNPS1, in T Cells of Ankylosing Spondylitis Patients Enhances the MEK/ERK Signaling and Inflammation Mediated by T Cell Activation via Stabilization of hnRNPK and VAV1. | Int J Mol Sci | 2026 | 42737453 | PubTator, text mining | PubMed |
| SETD5 regulates leukemic initiation and infiltration in T-cell acute lymphoblastic leukemia. | Exp Cell Res | 2026 | 42595290 | PubTator, text mining | PubMed |
| A Network Toxicology Framework for Identification of Immune System Disruption by Per- and Polyfluoroalkyl Substance (PFAS) Mixture: In Silico Analysis. | J Xenobiot | 2026 | 42346437 | PubTator, text mining | PubMed |
| Pan-cancer signaling landscape linked to endothelial and immune Sphingosine-1-phosphate receptor 1 (S1PR1) expression. | In Silico Pharmacol | 2026 | 42333231 | PubTator, text mining | PubMed |
| Kinase signaling networks governing neuroinflammatory glial phenotypes: Current understanding and emerging targets. | Histol Histopathol | 2026 | 42273825 | PubTator, text mining | PubMed |
| Phage Display Driven Identification and Computational Mapping of Macrocyclic Peptides Targeting RhoA G17V. | Biochemistry | 2026 | 41986244 | PubTator, text mining | PubMed |
| Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review). | Mol Med Rep | 2026 | 41891975 | PubTator, text mining | PubMed |
| Global molecular landscape of early MASLD progression in human obesity. | Elife | 2026 | 41870035 | PubTator, text mining | PubMed |
| Neuroinflammation and NeuroHIV: understanding the role of HIV-1 related factors in microglial activation. | Transl Psychiatry | 2026 | 41856995 | PubTator, text mining | PubMed |
1 to 10 of 3,486
See all 3,486 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7409
GET https://conductscience.org/api/genes/v1/7409/patents?page=2