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Gene · 7409

VAV1: vav guanine nucleotide exchange factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VAV1: vav guanine nucleotide exchange factor 1. Genes, record 7409. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7409

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Gene

Symbol
VAV1
HGNC
Name
vav guanine nucleotide exchange factor 1
HGNC
NCBI Gene ID
7409
NCBI Gene
HGNC ID
HGNC:12657
HGNC
Ensembl
ENSG00000141968
NCBI Gene
Aliases
VAV
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15498Proto-oncogene vav84510Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469600P15498Espacenet
JP 2026004568 A2026-01-1469603P15498Espacenet
EP 4661970 A12025-12-1762169P15498Espacenet
EP 4661970 A12025-12-1762176P15498Espacenet
EP 4641201 A22025-10-2922363P15498Espacenet
JP 2025147176 A2025-10-0616606P15498Espacenet
JP 2025517969 A2025-06-1222363P15498Espacenet
JP 2025028160 A2025-02-2816606P15498Espacenet
KR 1020250010750 A2025-01-2116606P15498Espacenet
JP 2024109657 A2024-08-1416445P15498Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,874

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVAV1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant282025
ZIABC010304Biochemical Basis of T Cell Activation162025
P30CA016672Cancer Center Support Grant112025
P30CA021765Cancer Center Support Grant (CCSG)102025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR82025
ZICBC010978Confocal Core for the Laboratory of Cellular and Molecular Biology82025
P30CA016042Cancer Center Support Grant72025
P30CA086862Cancer Center Support Grant72025
P30CA091842Cancer Center Support Grant72025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology72025

1 to 10 of 2,874Source NIH's project files

See all 2,874 nih grants

Papers3,486

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis.Int J Genomics202642807562PubTator, text miningPubMed
An Increased Circular RNA, circRNPS1, in T Cells of Ankylosing Spondylitis Patients Enhances the MEK/ERK Signaling and Inflammation Mediated by T Cell Activation via Stabilization of hnRNPK and VAV1.Int J Mol Sci202642737453PubTator, text miningPubMed
SETD5 regulates leukemic initiation and infiltration in T-cell acute lymphoblastic leukemia.Exp Cell Res202642595290PubTator, text miningPubMed
A Network Toxicology Framework for Identification of Immune System Disruption by Per- and Polyfluoroalkyl Substance (PFAS) Mixture: In Silico Analysis.J Xenobiot202642346437PubTator, text miningPubMed
Pan-cancer signaling landscape linked to endothelial and immune Sphingosine-1-phosphate receptor 1 (S1PR1) expression.In Silico Pharmacol202642333231PubTator, text miningPubMed
Kinase signaling networks governing neuroinflammatory glial phenotypes: Current understanding and emerging targets.Histol Histopathol202642273825PubTator, text miningPubMed
Phage Display Driven Identification and Computational Mapping of Macrocyclic Peptides Targeting RhoA G17V.Biochemistry202641986244PubTator, text miningPubMed
Heterogeneous nuclear ribonucleoprotein K in cancer biology and its therapeutic applications (Review).Mol Med Rep202641891975PubTator, text miningPubMed
Global molecular landscape of early MASLD progression in human obesity.Elife202641870035PubTator, text miningPubMed
Neuroinflammation and NeuroHIV: understanding the role of HIV-1 related factors in microglial activation.Transl Psychiatry202641856995PubTator, text miningPubMed

1 to 10 of 3,486

See all 3,486 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7409

GET https://conductscience.org/api/genes/v1/7409/patents?page=2