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VEGFA: vascular endothelial growth factor A

1 protein, 106 patents, 15 drugs, 3,270 trials, 39,302 NIH grants and 220,361 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolVEGFAHGNC
Namevascular endothelial growth factor AHGNC
NCBI Gene ID7422NCBI Gene
HGNC IDHGNC:12680HGNC
EnsemblENSG00000112715NCBI Gene
AliasesL-VEGF, MVCD1, VEGF, VEGF-A, VPFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P15692Vascular endothelial growth factor A, long form39556Ensembl, GeneID, HGNCUniProt

Patents 106

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4830719 A22026-10-2817P15692Espacenet
WO 2026219939 A12026-10-2257P15692Espacenet
WO 2026215173 A12026-10-1557P15692Espacenet
WO 2026215363 A12026-10-1557P15692Espacenet
WO 2026215526 A12026-10-1557P15692Espacenet
WO 2026189672 A12026-09-17182P15692Espacenet
WO 2026190350 A12026-09-17182P15692Espacenet
WO 2026169600 A12026-08-1320P15692Espacenet
JP 2026090361 A2026-06-0217P15692Espacenet
WO 2025257394 A12025-12-18177P15692Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABICIPAR PEGOLCHEMBL4297684Vascular endothelial growth factor A inhibitorINHIBITORChEMBL
AFLIBERCEPTCHEMBL1742982Vascular endothelial growth factor A inhibitorINHIBITORChEMBL
BEVACIZUMABCHEMBL1201583Vascular endothelial growth factor A inhibitorINHIBITORChEMBL
BEVACIZUMAB 111INCHEMBL3707253Vascular endothelial growth factor A binding agentBINDING AGENTChEMBL
BEVACIZUMAB GAMMACHEMBL5314727Vascular endothelial growth factor A binding agentBINDING AGENTChEMBL
BEVASIRANIBCHEMBL2110581VEGF-A mRNA RNAi inhibitorRNAI INHIBITORChEMBL
BEVASIRANIB SODIUMCHEMBL2103797VEGF-A mRNA RNAi inhibitorRNAI INHIBITORChEMBL
BROLUCIZUMABCHEMBL3707357Vascular endothelial growth factor A inhibitorINHIBITORChEMBL
CONBERCEPTCHEMBL2108313Vascular endothelial growth factor A inhibitorINHIBITORChEMBL
FARICIMABCHEMBL4297750Vascular endothelial growth factor A inhibitorINHIBITORChEMBL

Trials 3270

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07585279BEVACIZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT07581626BEVACIZUMABPHASE2ClinicalTrials.gov
NCT07564141BEVACIZUMABPHASE3ClinicalTrials.gov
NCT07562490BEVACIZUMABPHASE2ClinicalTrials.gov
NCT07560488BEVACIZUMABPHASE2ClinicalTrials.gov
NCT07559760BEVACIZUMABPHASE2ClinicalTrials.gov
NCT07557251BEVACIZUMABPHASE1ClinicalTrials.gov
NCT07557121AFLIBERCEPTPHASE2ClinicalTrials.gov
NCT07551778BEVACIZUMABPHASE1/PHASE2ClinicalTrials.gov
NCT07550504RANIBIZUMABPHASE2ClinicalTrials.gov

NIH grants 39302

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1,0792,025NIH's project files
P30CA008748Cancer Center Support Grant7122,025NIH's project files
P30CA006973Regional Oncology Research Center2262,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1832,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support1682,025NIH's project files
P30CA016058Cancer Center Support Grant1642,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1382,025NIH's project files
P30CA047904Cancer Center Support Grant1342,025NIH's project files
P30EY014801Miami Center for Vision Research1292,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1082,025NIH's project files

Papers 220361

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827331PubTator, text miningPubMed
42826046PubTator, text miningPubMed
42826021PubTator, text miningPubMed
42825501PubTator, text miningPubMed
42825489PubTator, text miningPubMed
42824866PubTator, text miningPubMed
42824309PubTator, text miningPubMed
42823960PubTator, text miningPubMed
42823793PubTator, text miningPubMed
42823093PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license