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VHL: von Hippel-Lindau tumor suppressor

1 protein, 55 patents, 0 drugs, 0 trials, 5,850 NIH grants and 15,284 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolVHLHGNC
Namevon Hippel-Lindau tumor suppressorHGNC
NCBI Gene ID7428NCBI Gene
HGNC IDHGNC:12687HGNC
EnsemblENSG00000134086NCBI Gene
AliasesHRCA1, RCA1, VHL1, pVHLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40337von Hippel-Lindau disease tumor suppressor213142Ensembl, GeneID, HGNCUniProt

Patents 55

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21405P40337Espacenet
WO 2025244125 A2025-11-2721P40337Espacenet
EP 4640849 A22025-10-29185P40337Espacenet
EP 4641201 A22025-10-291198P40337Espacenet
JP 2025147176 A2025-10-0616543P40337Espacenet
JP 2025519096 A2025-06-24185P40337Espacenet
JP 2025517969 A2025-06-121198P40337Espacenet
JP 2025028160 A2025-02-2816543P40337Espacenet
JP 2025503444 A2025-02-0413P40337Espacenet
KR 1020250010750 A2025-01-2116543P40337Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5850

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1682,025NIH's project files
P30CA016672Cancer Center Support Grant1492,025NIH's project files
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer972,025NIH's project files
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene942,025NIH's project files
ZIDBC011089Clinical Nursing and Data Management Core762,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)652,025NIH's project files
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene532,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase462,025NIH's project files
P30CA006973Regional Oncology Research Center322,025NIH's project files
P30CA016086Cancer Center Support Grant322,025NIH's project files

Papers 15284

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823600PubTator, text miningPubMed
42819788PubTator, text miningPubMed
42812292PubTator, text miningPubMed
42811544PubTator, text miningPubMed
42807011PubTator, text miningPubMed
42801576PubTator, text miningPubMed
42794678PubTator, text miningPubMed
42794484PubTator, text miningPubMed
42787653PubTator, text miningPubMed
42784467PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license