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Gene · 7439

BEST1: bestrophin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BEST1: bestrophin 1. Genes, record 7439. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7439

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Gene

Symbol
BEST1
HGNC
Name
bestrophin 1
HGNC
NCBI Gene ID
7439
NCBI Gene
HGNC ID
HGNC:12703
HGNC
Ensembl
ENSG00000167995
NCBI Gene
Aliases
ARB, BEST, BMD, Best1V1Delta2, RP50, TU15B, VMD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O76090Bestrophin-158519Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19195O76090Espacenet
JP 2026004568 A2026-01-1438939O76090Espacenet
EP 4667578 A22025-12-24178O76090Espacenet
JP 2025131621 A2025-09-09178O76090Espacenet
JP 2025529142 A2025-09-04577O76090Espacenet
EP 4590841 A22025-07-3014O76090Espacenet
US 12371689 B22025-07-29577O76090Espacenet
JP 2025514710 A2025-05-09178O76090Espacenet
JP 2025062604 A2025-04-148936O76090Espacenet
US 12246072 B22025-03-1112O76090Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants844

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBEST1 papersNewest fiscal year
R01EY018213Defining Barriers to Gene Therapy152025
P30EY001583P30 Core Grant For Vision Research112025
P30CA013696Cancer Center Support Grant102025
P30EY000331Vision Research Core at UCLA102025
R01EY006855Models for Therapy of Hereditary Retinal Degeneration102025
R01EY024698Gene Editing and Silencing in Phototransduction102025
P30EY005722Center Core Grant for Vision Research62025
P30EY006360P30-Core Grant for Vision Research62025
P30EY022589NEI Center Core Grant for Vision Research62025
P30EY025580Multidisciplinary Investigations in Visual Science62025

1 to 10 of 844Source NIH's project files

See all 844 nih grants

Papers1,518

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D-Serine Signaling.Adv Sci (Weinh)202642811508PubTator, text miningPubMed
Expanding the genotype-phenotype spectrum of autosomal recessive bestrophinopathy: a clinicogenetic report of Filipino siblings with compound heterozygous BEST1 variants.Eye (Lond)202642811081PubTator, text miningPubMed
Case Report: Acute angle-closure glaucoma as the initial presentation of autosomal recessive bestrophinopathy caused by compound heterozygous BEST1 mutations.Front Med (Lausanne)202642774095PubTator, text miningPubMed
Characterization of Ocular Developmental Disorders in the Israeli Population: Genotype-Phenotype Correlations and Novel Candidate Genes.Biomolecules202642650885PubTator, text miningPubMed
Dissecting Missing Heritability in Rare Inherited Macular Dystrophies.Genes (Basel)202642650171PubTator, text miningPubMed
Dual-restricted AAV gene delivery via suprachoroidal administration mediates precision RPE SOCS3 restoration for dry age-related macular degeneration.J Control Release202642636893PubTator, text miningPubMed
CircMETTL3 Inhibits H2O2-Induced Senescence, Oxidative Stress, and DNA Damage in ARPE-19 Cells via miR-100/BMPR2 Axis.J Ophthalmol202642626541PubTator, text miningPubMed
AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD.Proc Natl Acad Sci U S A202642579492PubTator, text miningPubMed
Bestrophinopathies: Clinical Characteristics, Natural History, and Genetic Landscape.Ophthalmol Retina202642559932PubTator, text miningPubMed
Ocular Safety and Efficacy of AAV-mediated Tyrosinase Gene Augmentation in a Nonhuman Primate Model.bioRxiv202642523373PubTator, text miningPubMed

1 to 10 of 1,518

See all 1,518 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7439

GET https://conductscience.org/api/genes/v1/7439/patents?page=2