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TRPV1: transient receptor potential cation channel subfamily V member 1

1 protein, 88 patents, 19 drugs, 410 trials, 4,167 NIH grants and 12,136 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTRPV1HGNC
Nametransient receptor potential cation channel subfamily V member 1HGNC
NCBI Gene ID7442NCBI Gene
HGNC IDHGNC:12716HGNC
EnsemblENSG00000196689NCBI Gene
AliasesVR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8NER1Transient receptor potential cation channel subfamily V member 183913Ensembl, GeneID, HGNCUniProt

Patents 88

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467585Q8NER1Espacenet
JP 2026004568 A2026-01-1467655Q8NER1Espacenet
JP 2026004568 A2026-01-1467656Q8NER1Espacenet
US 12435124 B22025-10-0734Q8NER1Espacenet
JP 2025529142 A2025-09-045076Q8NER1Espacenet
US 12371689 B22025-07-295076Q8NER1Espacenet
JP 2025024198 A2025-02-1916520Q8NER1Espacenet
JP 2023538115 A2023-09-06631Q8NER1Espacenet
KR 1020230052291 A2023-04-1934Q8NER1Espacenet
JP 2023506433 A2023-02-1641Q8NER1Espacenet

Drugs 19

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-102CHEMBL398338Vanilloid receptor antagonistANTAGONISTChEMBL
ACETAMINOPHENCHEMBL112Vanilloid receptor openerOPENERChEMBL
AMG-517CHEMBL229430Vanilloid receptor antagonistANTAGONISTChEMBL
AZD1386CHEMBL3545039Vanilloid receptor antagonistANTAGONISTChEMBL
CAPSAICINCHEMBL294199Vanilloid receptor openerOPENERChEMBL
DWP05195CHEMBL5314400Vanilloid receptor antagonistANTAGONISTChEMBL
GRC-6211CHEMBL5314398Vanilloid receptor antagonistANTAGONISTChEMBL
JTS-653CHEMBL5314399Vanilloid receptor antagonistANTAGONISTChEMBL
MAVATREPCHEMBL2364618Vanilloid receptor antagonistANTAGONISTChEMBL
MR-1817CHEMBL3707397Vanilloid receptor antagonistANTAGONISTChEMBL

Trials 410

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07602387CAPSAICINClinicalTrials.gov
NCT07546370ACETAMINOPHENPHASE4ClinicalTrials.gov
NCT07533487ACETAMINOPHENClinicalTrials.gov
NCT07463482ACETAMINOPHENClinicalTrials.gov
NCT07440446ACETAMINOPHENClinicalTrials.gov
NCT07435493ACETAMINOPHENClinicalTrials.gov
NCT07406971CAPSAICINPHASE2ClinicalTrials.gov
NCT07353372ACETAMINOPHENClinicalTrials.gov
NCT07260656CAPSAICINEARLY_PHASE1ClinicalTrials.gov
NCT07154433ACETAMINOPHENClinicalTrials.gov

NIH grants 4167

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV5232,025NIH's project files
ZIACL090033Integrative And Molecular Studies Of Pain And Pain Control222,025NIH's project files
R01CA206573Structure and function of Transient Receptor Potential Channels162,025NIH's project files
T32DE014318Craniofacial Oral-biology Student Training in Academic Research (COSTAR)162,025NIH's project files
ZIACL090035The Pain Neural Transcriptome142,025NIH's project files
ZIADE000721Molecular Genetic Studies of Somatosensation132,025NIH's project files
R01NS070711Nociceptive Mechanisms Underlying Sickle Cell Pain122,025NIH's project files
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States122,025NIH's project files
ZIANS002945Gating mechanisms and pharmacology of voltage-activated ion channels122,025NIH's project files
P30EY014800University of Utah Core Vision Research Grant112,025NIH's project files

Papers 12136

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826868PubTator, text miningPubMed
42822051PubTator, text miningPubMed
42819829PubTator, text miningPubMed
42819332PubTator, text miningPubMed
42818061PubTator, text miningPubMed
42805573PubTator, text miningPubMed
42802866PubTator, text miningPubMed
42800590PubTator, text miningPubMed
42800300PubTator, text miningPubMed
42797289PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license