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VWF: von Willebrand factor

1 protein, 79 patents, 4 drugs, 34 trials, 10,770 NIH grants and 37,561 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolVWFHGNC
Namevon Willebrand factorHGNC
NCBI Gene ID7450NCBI Gene
HGNC IDHGNC:12726HGNC
EnsemblENSG00000110799NCBI Gene
AliasesF8VWF, VWDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04275von Willebrand factor2,81348Ensembl, GeneID, HGNCUniProt

Patents 79

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026513540 A2026-04-285P04275Espacenet
KR 1020250168493 A2025-12-025P04275Espacenet
WO 2025245169 A12025-11-2719P04275Espacenet
EP 4650780 A22025-11-191884P04275Espacenet
JP 2025169942 A2025-11-141391P04275Espacenet
EP 4641201 A22025-10-291472P04275Espacenet
JP 2025147176 A2025-10-0614196P04275Espacenet
EP 4621056 A12025-09-2428P04275Espacenet
JP 2025529142 A2025-09-048056P04275Espacenet
WO 2025181343 A12025-09-046P04275Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CAPLACIZUMABCHEMBL2109624von Willebrand factor inhibitorINHIBITORChEMBL
EGAPTIVON PEGOLCHEMBL2108339von Willebrand factor inhibitorINHIBITORChEMBL
VON WILLEBRAND FACTOR HUMANCHEMBL4298126von Willebrand factor exogenous proteinEXOGENOUS PROTEINChEMBL
VONICOG ALFACHEMBL2107873von Willebrand factor exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 34

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07404644VONICOG ALFAClinicalTrials.gov
NCT07129343VON WILLEBRAND FACTOR HUMANPHASE3ClinicalTrials.gov
NCT06173024VON WILLEBRAND FACTOR HUMANClinicalTrials.gov
NCT06118372VON WILLEBRAND FACTOR HUMANPHASE1ClinicalTrials.gov
NCT05876221CAPLACIZUMABClinicalTrials.gov
NCT05785468CAPLACIZUMABClinicalTrials.gov
NCT05582993VONICOG ALFAPHASE3ClinicalTrials.gov
NCT04953884VON WILLEBRAND FACTOR HUMANPHASE32026-02-20ClinicalTrials.gov
NCT04720261CAPLACIZUMABPHASE2ClinicalTrials.gov
NCT04657887VON WILLEBRAND FACTOR HUMANClinicalTrials.gov

NIH grants 10770

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award422,025NIH's project files
P30CA008748Cancer Center Support Grant292,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI272,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy202,025NIH's project files
P51OD011092Support for National Primate Research Center172,025NIH's project files
R01HL019278Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand Factor172,025NIH's project files
P30CA015704Cancer Center Support Grant152,025NIH's project files
P30DK063491Diabetes Research Center (DRC)152,025NIH's project files
P30CA068485Cancer Center Support Grant142,025NIH's project files

Papers 37561

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827462PubTator, text miningPubMed
42820581PubTator, text miningPubMed
42818071PubTator, text miningPubMed
42816685PubTator, text miningPubMed
42816008PubTator, text miningPubMed
42812790PubTator, text miningPubMed
42812766PubTator, text miningPubMed
42811433PubTator, text miningPubMed
42809655PubTator, text miningPubMed
42808109PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license