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Gene · 7453

WARS1: tryptophanyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WARS1: tryptophanyl-tRNA synthetase 1. Genes, record 7453. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7453

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Gene

Symbol
WARS1
HGNC
Name
tryptophanyl-tRNA synthetase 1
HGNC
NCBI Gene ID
7453
NCBI Gene
HGNC ID
HGNC:12729
HGNC
Ensembl
ENSG00000140105
NCBI Gene
Aliases
GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23381Tryptophan--tRNA ligase, cytoplasmic47113Ensembl, GeneID, HGNC

Source UniProt

Patents118

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468417P23381Espacenet
JP 2026004568 A2026-01-1468419P23381Espacenet
JP 2026004568 A2026-01-1468441P23381Espacenet
EP 4650780 A22025-11-197159P23381Espacenet
EP 4641201 A22025-10-297075P23381Espacenet
EP 4641202 A22025-10-295231P23381Espacenet
JP 2025120083 A2025-08-151P23381Espacenet
KR 1020250101933 A2025-07-042P23381Espacenet
JP 2025517969 A2025-06-127075P23381Espacenet
JP 2025517970 A2025-06-127159P23381Espacenet

1 to 10 of 118

See all 118 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,662

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWARS1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
R01NS105789Understanding GABAA receptor protein folding and misfolding92025
R28AA012725Brain Tissue Resource Center for Alcohol Research72025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)52025
R35GM122528Dynamics Of Ligand Gated Ion Channels52025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health52025
P30CA068485Cancer Center Support Grant42025
P30EY008126Core Grant in Vision Research42025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders42025
R01DA047325Structure and Function of GABA-A receptors42025

1 to 10 of 2,662Source NIH's project files

See all 2,662 nih grants

Papers3,740

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Accurate measurement of longitudinal paramagnetic relaxation enhancement through division after subtraction.Magn Reson Lett202742534397PubTator, text miningPubMed
PRELP-associated transcriptomic remodeling links alternative splicing and immune checkpoint blockade outcome in melanoma.Front Immunol202642813001PubTator, text miningPubMed
Integrative Proteogenomics and Single-Cell Transcriptomics Prioritize Candidate Causal Proteins and Therapeutic Targets in Age-Related Macular Degeneration.Int J Mol Sci202642794533PubTator, text miningPubMed
AMPK γ-Subunit Isoform Switching Governs Temozolomide Resistance and Survival in Glioblastoma.Cells202642738889PubTator, text miningPubMed
COPI Coatomer Regulates Several Steps of HDL Metabolism.Arterioscler Thromb Vasc Biol202642592650PubTator, text miningPubMed
Tissue origins of the plasma proteomic response to glucose ingestion in humans.Diabetologia202642467085PubTator, text miningPubMed
GABAA receptor dysfunction in autism spectrum disorder: molecular mechanisms and therapeutic opportunities.Front Pharmacol202642338965PubTator, text miningPubMed
Structural basis for activation and potentiation in a human α5β3 GABAA receptor.Nat Commun202642297817PubTator, text miningPubMed
Long-Chain S-Acylation Is a Key Modulator During the Macrophage Inflammatory Response.Mol Cell Proteomics202642269967PubTator, text miningPubMed
Plasma proteomic profiles reveal proteins and characteristic patterns associated with hypertension: A prospective cohort study.J Hypertens202642160135PubTator, text miningPubMed

1 to 10 of 3,740

See all 3,740 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7453

GET https://conductscience.org/api/genes/v1/7453/patents?page=2