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WEE1: WEE1 G2 checkpoint kinase

1 protein, 30 patents, 2 drugs, 63 trials, 2,708 NIH grants and 5,285 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolWEE1HGNC
NameWEE1 G2 checkpoint kinaseHGNC
NCBI Gene ID7465NCBI Gene
HGNC IDHGNC:12761HGNC
EnsemblENSG00000166483NCBI Gene
AliasesWEE1A, WEE1huNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P30291Wee1-like protein kinase64629Ensembl, GeneID, HGNCUniProt

Patents 30

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913137P30291Espacenet
EP 4641202 A22025-10-296542P30291Espacenet
US 12433888 B12025-10-074P30291Espacenet
JP 2025517970 A2025-06-1213137P30291Espacenet
EP 4555325 A22025-05-214P30291Espacenet
KR 1020250017231 A2025-02-046542P30291Espacenet
JP 2024123008 A2024-09-109066P30291Espacenet
US 11446398 B22022-09-2097633P30291Espacenet
JP 2022524081 A2022-04-27200604P30291Espacenet
JP 2021018154 A2021-02-15982P30291Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADAVOSERTIBCHEMBL1976040Serine/threonine-protein kinase WEE1 inhibitorINHIBITORChEMBL
AZENOSERTIBCHEMBL5095036Serine/threonine-protein kinase WEE1 inhibitorINHIBITORChEMBL

Trials 63

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07546500AZENOSERTIBPHASE3ClinicalTrials.gov
NCT06369155AZENOSERTIBPHASE2ClinicalTrials.gov
NCT06364410AZENOSERTIBPHASE1ClinicalTrials.gov
NCT06351332AZENOSERTIBPHASE1ClinicalTrials.gov
NCT06015659AZENOSERTIBPHASE2ClinicalTrials.gov
NCT05743036AZENOSERTIBPHASE1ClinicalTrials.gov
NCT05682170AZENOSERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT05368506AZENOSERTIBEARLY_PHASE1ClinicalTrials.gov
NCT05212025ADAVOSERTIBPHASE2ClinicalTrials.gov
NCT05198804AZENOSERTIBPHASE1/PHASE2ClinicalTrials.gov

NIH grants 2708

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant862,025NIH's project files
P30CA008748Cancer Center Support Grant402,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant202,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028172,025NIH's project files
P30CA056036Translational Research in Cancer142,025NIH's project files
P30CA015704Cancer Center Support Grant132,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant132,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program122,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant122,025NIH's project files
P30CA086862Cancer Center Support Grant112,025NIH's project files

Papers 5285

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824309PubTator, text miningPubMed
42819173PubTator, text miningPubMed
42814286PubTator, text miningPubMed
42794728PubTator, text miningPubMed
42792657PubTator, text miningPubMed
42789387PubTator, text miningPubMed
42789178PubTator, text miningPubMed
42781243PubTator, text miningPubMed
42773250PubTator, text miningPubMed
42773173PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license