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Gene · 7466

WFS1: wolframin ER transmembrane glycoprotein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WFS1: wolframin ER transmembrane glycoprotein. Genes, record 7466. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7466

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Gene

Symbol
WFS1
HGNC
Name
wolframin ER transmembrane glycoprotein
HGNC
NCBI Gene ID
7466
NCBI Gene
HGNC ID
HGNC:12762
HGNC
Ensembl
ENSG00000109501
NCBI Gene
Aliases
CTRCT41, DFNA14, DFNA38, DFNA6, DIDMOAD, WFRS, WFS, WFSL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O76024Wolframin8900Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1991O76024Espacenet
JP 2026004568 A2026-01-1469966O76024Espacenet
JP 2026004568 A2026-01-1469967O76024Espacenet
EP 4640849 A22025-10-2980O76024Espacenet
EP 4641201 A22025-10-29470O76024Espacenet
JP 2025529142 A2025-09-045264O76024Espacenet
US 12371689 B22025-07-295264O76024Espacenet
JP 2025519096 A2025-06-2480O76024Espacenet
JP 2025517969 A2025-06-12470O76024Espacenet
JP 2025032204 A2025-03-1138174O76024Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,165

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWFS1 papersNewest fiscal year
P30DK020579Diabetes Research Center382025
UL1TR002345Washington University Institute of Clinical and Translational Sciences202025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION142025
P30DK020572Michigan Diabetes Research Center (MDRC)112025
R01DC012049Optimizing Genetic Testing for Deafness for Clinical Diagnostics112025
ZIAHG000024Genetic analysis of type II diabetes102025
P30DK020595Diabetes Research and Training Center72025
P30DK063491Diabetes Research Center (DRC)72025
R01DC003594Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes72025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits62025

1 to 10 of 1,165Source NIH's project files

See all 1,165 nih grants

Papers1,771

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Case Report: Rapid loss of endogenous insulin secretion and reversible subcutaneous insulin resistance following exogenous insulin exposure in a patient initially diagnosed with type 2 diabetes.Front Endocrinol (Lausanne)202642824193PubTator, text miningPubMed
Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity.Life (Basel)202642795351PubTator, text miningPubMed
Adult-onset Wolfram syndrome presenting as isolated bilateral optic atrophy.Can J Ophthalmol202642785371PubTator, text miningPubMed
Co-segregation of WFS1 p.Gly494Ser variant with recurrent vasovagal syncope in a multigenerational family: a candidate susceptibility variant needing independent validation.Front Pediatr202642756402PubTator, text miningPubMed
Genetic Heterogeneity in Susceptibility to Familial Thyroid Nodular Disease.Thyroid202642723469PubTator, text miningPubMed
Neuro-ophthalmological manifestations and therapeutic development in Wolfram syndrome.Best Pract Res Clin Endocrinol Metab202642648929PubTator, text miningPubMed
Evaluating the use of GLP-1 receptor agonists in Wolfram syndrome patients.Front Endocrinol (Lausanne)202642597412PubTator, text miningPubMed
Genotype-based severity scoring system in Wolfram Syndrome: correlation with onset of cardinal symptoms and WFS1 gene variant types.Front Genet202642524523PubTator, text miningPubMed
Retraction notice to "Proteomic hub proteins CDKN2B, TRAPPC2L, WFS1, and ARPP19 drive biochemical recurrence and metastatic progression in prostate cancer: Protein macromolecule action" [Int. J. Biol. Macromol. 311 (2025) 144059].
Int J Biol Macromol202642481344PubTator, text miningPubMed
Consensus Recommendations for the Clinical Management of Wolfram syndrome Using a Delphi Method.medRxiv202642428113PubTator, text miningPubMed

1 to 10 of 1,771

See all 1,771 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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