Gene · 7466
WFS1: wolframin ER transmembrane glycoprotein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. WFS1: wolframin ER transmembrane glycoprotein. Genes, record 7466. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7466
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O76024 | Wolframin | 890 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 91 | O76024 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69966 | O76024 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 69967 | O76024 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 80 | O76024 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 470 | O76024 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5264 | O76024 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5264 | O76024 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 80 | O76024 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 470 | O76024 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 38174 | O76024 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,165
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | WFS1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020579 | Diabetes Research Center | 38 | 2025 |
| UL1TR002345 | Washington University Institute of Clinical and Translational Sciences | 20 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 14 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 11 | 2025 |
| R01DC012049 | Optimizing Genetic Testing for Deafness for Clinical Diagnostics | 11 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 10 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 7 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 7 | 2025 |
| R01DC003594 | Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes | 7 | 2025 |
| R01DK093757 | Genetic epidemiology of rare and regulatory variants for metabolic traits | 6 | 2025 |
1 to 10 of 1,165Source NIH's project files
See all 1,165 nih grantsPapers1,771
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Case Report: Rapid loss of endogenous insulin secretion and reversible subcutaneous insulin resistance following exogenous insulin exposure in a patient initially diagnosed with type 2 diabetes. | Front Endocrinol (Lausanne) | 2026 | 42824193 | PubTator, text mining | PubMed |
| Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity. | Life (Basel) | 2026 | 42795351 | PubTator, text mining | PubMed |
| Adult-onset Wolfram syndrome presenting as isolated bilateral optic atrophy. | Can J Ophthalmol | 2026 | 42785371 | PubTator, text mining | PubMed |
| Co-segregation of WFS1 p.Gly494Ser variant with recurrent vasovagal syncope in a multigenerational family: a candidate susceptibility variant needing independent validation. | Front Pediatr | 2026 | 42756402 | PubTator, text mining | PubMed |
| Genetic Heterogeneity in Susceptibility to Familial Thyroid Nodular Disease. | Thyroid | 2026 | 42723469 | PubTator, text mining | PubMed |
| Neuro-ophthalmological manifestations and therapeutic development in Wolfram syndrome. | Best Pract Res Clin Endocrinol Metab | 2026 | 42648929 | PubTator, text mining | PubMed |
| Evaluating the use of GLP-1 receptor agonists in Wolfram syndrome patients. | Front Endocrinol (Lausanne) | 2026 | 42597412 | PubTator, text mining | PubMed |
| Genotype-based severity scoring system in Wolfram Syndrome: correlation with onset of cardinal symptoms and WFS1 gene variant types. | Front Genet | 2026 | 42524523 | PubTator, text mining | PubMed |
Retraction notice to "Proteomic hub proteins CDKN2B, TRAPPC2L, WFS1, and ARPP19 drive biochemical recurrence and metastatic progression in prostate cancer: Protein macromolecule action" [Int. J. Biol. Macromol. 311 (2025) 144059]. | Int J Biol Macromol | 2026 | 42481344 | PubTator, text mining | PubMed |
| Consensus Recommendations for the Clinical Management of Wolfram syndrome Using a Delphi Method. | medRxiv | 2026 | 42428113 | PubTator, text mining | PubMed |
1 to 10 of 1,771
See all 1,771 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7466
GET https://conductscience.org/api/genes/v1/7466/patents?page=2