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Gene · 7486

Papers3,630

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.Commun Biol202641606312PubTator, text miningPubMed
Novel Homozygous Variants in CIDEC and WRN in a Young Female with Lipodystrophy and Thyroid Cancer.Int J Mol Sci202641596298PubTator, text miningPubMed
BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication.J Biol Chem202641570993PubTator, text miningPubMed
Photoclick chemistry led to the identification of HELLS as a helicase for DNA G-quadruplexes.Nucleic Acids Res202641569154PubTator, text miningPubMed
SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription.Nat Commun202641565615PubTator, text miningPubMed
The Werner syndrome RECQ helicase as a therapeutic target: new insights.Expert Opin Ther Targets202641557499PubTator, text miningPubMed
Stability of non-canonical nucleic acid structure as a potential modulator of cell fate.Nucleic Acids Res202641533566PubTator, text miningPubMed
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors.Nat Commun202641484101PubTator, text miningPubMed
Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.J Diabetes Investig202641316811PubTator, text miningPubMed
The bacterial MRE11-RAD50 and DNA2-WRN homologs process replication forks at distinct and separate loci on the chromosome.FEBS Lett202641168947PubTator, text miningPubMed
Drugging the DNA damage response in the clinic: going beyond PARP.Expert Rev Anticancer Ther202641086259PubTator, text miningPubMed
AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen.Bioorg Med Chem Lett202641038585PubTator, text miningPubMed
Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.Cytogenet Genome Res202640971347PubTator, text miningPubMed
Post-Translational Modifications of the Werner Syndrome Protein WRN.Cytogenet Genome Res202640602371PubTator, text miningPubMed
Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents.Mol Divers202640517347PubTator, text miningPubMed
Discovery of novel quinazoline derivatives containing trifluoromethyl against cell proliferation by targeting werner helicase.Mol Divers202640148606PubTator, text miningPubMed
Genetic and Epigenetic Insights into Werner Syndrome.Cytogenet Genome Res202639956107PubTator, text miningPubMed
Application and Prospects of Large Language Models in Small-Molecule Drug Discovery.Anal Chem202541366732PubTator, text miningPubMed
Context-aware gene dependency modeling via graph attention networks for precision oncology.J Transl Med202541291726PubTator, text miningPubMed
Targeting DNA Damage Repair Pathways Beyond PARP Inhibition.Target Oncol202541240294PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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