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Gene · 7486

WRN: WRN RecQ like helicase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WRN: WRN RecQ like helicase. Genes, record 7486. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7486

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Gene

Symbol
WRN
HGNC
Name
WRN RecQ like helicase
HGNC
NCBI Gene ID
7486
NCBI Gene
HGNC ID
HGNC:12791
HGNC
Ensembl
ENSG00000165392
NCBI Gene
Aliases
RECQ3, RECQL2, RECQL3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14191Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN1,43251Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026213541 A12026-10-08466Q14191Espacenet
WO 2026147994 A12026-07-091Q14191Espacenet
WO 2026148002 A12026-07-091Q14191Espacenet
JP 2026090543 A2026-06-02600Q14191Espacenet
JP 2026004568 A2026-01-1469868Q14191Espacenet
EP 4650780 A22025-11-193863Q14191Espacenet
EP 4641201 A22025-10-293432Q14191Espacenet
WO 2025191176 A12025-09-181Q14191Espacenet
JP 2025118686 A2025-08-131Q14191Espacenet
JP 2025522911 A2025-07-171Q14191Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,232

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWRN papersNewest fiscal year
ZIAAG000726Function of RecQ helicases in genome stability832025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability782025
P01CA092584Structural Cell Biology of DNA Repair Machines492025
ZIAAG000752Model Genetic Systems to Study DNA Repair372025
ZIAAG000753Fanconi Anemia Pathway342025
R01CA210916International Registry for Werner Syndrome222025
P30CA008748Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant152025
P42ES004705Toxic substances in the environment112025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures92025

1 to 10 of 2,232Source NIH's project files

See all 2,232 nih grants

Papers3,630

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial.Nat Med202642811189PubTator, text miningPubMed
Replication stress in cancer: origins, consequences and therapeutic opportunities.Nat Rev Cancer202642773173PubTator, text miningPubMed
NEAT1_1-encoded microprotein PSNEAT1 drives rDNA transcription via phase separation with WRN.Proc Natl Acad Sci U S A202642771507PubTator, text miningPubMed
Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.Drug Discov Today202642727625PubTator, text miningPubMed
The1H, 15N and13C backbone resonance assignments of an intrinsically disordered region (124-270) of BRCA1 associated RING domain 1 (BARD1).Biomol NMR Assign202642678585PubTator, text miningPubMed
Evolutionary study of oncogenes and tumor suppressor genes in breast carcinoma.J Taibah Univ Med Sci202642633313PubTator, text miningPubMed
Werner Syndrome Masquerading as Type 2 Diabetes: A Diagnostic Odyssey Leading to Precision Medicine.Am J Case Rep202642629965PubTator, text miningPubMed
Engineering bubble structures as Cas12a activators for highly sensitive monitoring of WRN helicase function.Biosens Bioelectron202642612455PubTator, text miningPubMed
[WRN and Other RecQ Helicases in Life Cycles of Viruses].Mol Biol (Mosk)202642599232PubTator, text miningPubMed
Potential advantage of clinical exome sequencing in BRCA1/2-negative families: a retrospective study of a cohort of 500 patients at a high-risk for hereditary cancers.J Med Genet202642498519PubTator, text miningPubMed

1 to 10 of 3,630

See all 3,630 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7486

GET https://conductscience.org/api/genes/v1/7486/patents?page=2