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Gene · 7507

XPA: XPA, DNA damage recognition and repair factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. XPA: XPA, DNA damage recognition and repair factor. Genes, record 7507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7507

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Gene

Symbol
XPA
HGNC
Name
XPA, DNA damage recognition and repair factor
HGNC
NCBI Gene ID
7507
NCBI Gene
HGNC ID
HGNC:12814
HGNC
Ensembl
ENSG00000136936
NCBI Gene
Aliases
XP1, XPAC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23025DNA repair protein complementing XP-A cells27318Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199581P23025Espacenet
EP 4641201 A22025-10-299833P23025Espacenet
JP 2025517969 A2025-06-129833P23025Espacenet
JP 2025517970 A2025-06-129581P23025Espacenet
EP 4524569 A22025-03-1928P23025Espacenet
EP 4464338 A22024-11-20375P23025Espacenet
JP 2024123008 A2024-09-109103P23025Espacenet
US 12023339 B22024-07-0228P23025Espacenet
US 11976334 B22024-05-07217P23025Espacenet
US 11680268 B22023-06-20375P23025Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,816

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleXPA papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines432025
P30CA016672Cancer Center Support Grant262025
P30ES010126UNC Center for Environmental Health and Susceptibility242025
R01CA093729Repair of Genome Destabilizing DNA Structures192025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock122025
P30CA068485Cancer Center Support Grant112025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant112025
P30CA047904Cancer Center Support Grant102025
P30CA118100University of New Mexico Cancer Center Support Grant102025
P30CA014599Cancer Center Support Grant92025

1 to 10 of 1,816Source NIH's project files

See all 1,816 nih grants

Papers3,297

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction to: An XPA gene splicing mutation resulting in trace protein expression in an elderly patient with xeroderma pigmentosum group A without neurological abnormalities.Br J Dermatol202642715004PubTator, text miningPubMed
XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA.Exp Biol Med (Maywood)202642643815PubTator, text miningPubMed
Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance.Proc Natl Acad Sci U S A202642607204PubTator, text miningPubMed
AAV-mediated gene therapy demonstrates phenotypic rescue in a mouse model of Cockayne syndrome.J Clin Invest202642531030PubTator, text miningPubMed
Whole-exome sequencing reveals novel and previously reported variants in genes linked to white matter pathology in neurodevelopmental disorders.Eur J Hum Genet202642420565PubTator, text miningPubMed
Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.J Cell Biol202642377264PubTator, text miningPubMed
Vitamin D Supplementation Modulates Base Excision Repair (BER) Machinery in Systemic Sclerosis: A Prospective Longitudinal Study.Biochem Genet202642258083PubTator, text miningPubMed
XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells.DNA Repair (Amst)202642247759PubTator, text miningPubMed
Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance.bioRxiv202642239149PubTator, text miningPubMed
Engineering quantum dot surfaces to preserve protein-DNA interactions for single-molecule visualization.Nano Converg202642234051PubTator, text miningPubMed

1 to 10 of 3,297

See all 3,297 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7507

GET https://conductscience.org/api/genes/v1/7507/patents?page=2