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Gene · 7508

XPC: XPC complex subunit, DNA damage recognition and repair factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. XPC: XPC complex subunit, DNA damage recognition and repair factor. Genes, record 7508. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7508

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Gene

Symbol
XPC
HGNC
Name
XPC complex subunit, DNA damage recognition and repair factor
HGNC
NCBI Gene ID
7508
NCBI Gene
HGNC ID
HGNC:12816
HGNC
Ensembl
ENSG00000154767
NCBI Gene
Aliases
RAD4, XP3, XPCC, p125
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01831DNA repair protein complementing XP-C cells94018Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193245Q01831Espacenet
EP 4641201 A22025-10-292821Q01831Espacenet
JP 2025517969 A2025-06-122821Q01831Espacenet
JP 2025517970 A2025-06-123245Q01831Espacenet
EP 4464338 A22024-11-20377Q01831Espacenet
JP 2024123008 A2024-09-109104Q01831Espacenet
EP 4384828 A12024-06-195Q01831Espacenet
US 11884978 B22024-01-30807Q01831Espacenet
US 11680268 B22023-06-20377Q01831Espacenet
US 11504404 B22022-11-22169Q01831Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,013

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleXPC papersNewest fiscal year
P30CA016672Cancer Center Support Grant362025
P01CA092584Structural Cell Biology of DNA Repair Machines342025
P30ES010126UNC Center for Environmental Health and Susceptibility222025
P30CA014599Cancer Center Support Grant172025
R01CA093729Repair of Genome Destabilizing DNA Structures152025
R01ES025987Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase Bypass132025
P30CA047904Cancer Center Support Grant122025
P30CA008748Cancer Center Support Grant112025
P30ES009089Center for Environmental Health in Northern Manhattan112025
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock112025

1 to 10 of 2,013Source NIH's project files

See all 2,013 nih grants

Papers3,752

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effect of xeroderma pigmentosum group C on the characteristics and regulatory mechanisms of lung cancer stem cells.Int J Oncol202642695433PubTator, text miningPubMed
TIP60 promotes chemoresistance by limiting intracellular platinum accumulation and enhancing removal of cisplatin-DNA adducts.J Biol Chem202642463050PubTator, text miningPubMed
Molecular mechanisms of DNA damage recognition and chromatin dynamics regulating mammalian nucleotide excision repair.DNA Repair (Amst)202642419012PubTator, text miningPubMed
DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis.DNA Repair (Amst)202642269320PubTator, text miningPubMed
Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide.Sci Rep202642259994PubTator, text miningPubMed
Vitamin D Supplementation Modulates Base Excision Repair (BER) Machinery in Systemic Sclerosis: A Prospective Longitudinal Study.Biochem Genet202642258083PubTator, text miningPubMed
XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells.DNA Repair (Amst)202642247759PubTator, text miningPubMed
microRNA miR-31-5p confers protection to melanin-deficient vitiligo keratinocytes against UV-B induced DNA damage by activating autophagy machinery.Sci Rep202642230707PubTator, text miningPubMed
[The Level of Methylation in the Promoter Regions of DNA Repair Genes in Chronically Exposed People].Mol Biol (Mosk)202642227125PubTator, text miningPubMed
Higher Levels of BRCA1 Gene Methylation in Sporadic Breast Cancer Patients with a Lower Incidence of Recurrence.Med Sci (Basel)202642201043PubTator, text miningPubMed

1 to 10 of 3,752

See all 3,752 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7508

GET https://conductscience.org/api/genes/v1/7508/patents?page=2