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Gene · 7516

XRCC2: X-ray repair cross complementing 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. XRCC2: X-ray repair cross complementing 2. Genes, record 7516. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7516

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Gene

Symbol
XRCC2
HGNC
Name
X-ray repair cross complementing 2
HGNC
NCBI Gene ID
7516
NCBI Gene
HGNC ID
HGNC:12829
HGNC
Ensembl
ENSG00000196584
NCBI Gene
Aliases
FANCU, POF17, SPGF50
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43543DNA repair protein XRCC228016Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-109127O43543Espacenet
US 11976334 B22024-05-07219O43543Espacenet
US 11597924 B22023-03-0760O43543Espacenet
US 11446398 B22022-09-2098041O43543Espacenet
JP 2022524081 A2022-04-27201012O43543Espacenet
WO 2021209517 A12021-10-2115O43543Espacenet
US 11078247 B22021-08-0312683O43543Espacenet
JP 2020508335 A2020-03-19219O43543Espacenet
US 10501513 B22019-12-109127O43543Espacenet
KR 1020190120204 A2019-10-23219O43543Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,114

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleXRCC2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant212025
P01CA092584Structural Cell Biology of DNA Repair Machines182025
P30CA016672Cancer Center Support Grant142025
P50CA116201Mayo Clinic Breast Cancer SPORE82025
R35GM118026Mechanisms of Genome Integrity82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant62025
P30ES006694Southwest Environmental Health Sciences Center62025
ZIACP010144Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes62025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN52025

1 to 10 of 1,114Source NIH's project files

See all 1,114 nih grants

Papers1,770

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.Diagnostics (Basel)202642793752PubTator, text miningPubMed
Whole-blood total chromium and DNA repair variation in an occupational Cr(VI)-exposure setting: Pathway-resolved associations across complementary response biomarkers.J Hazard Mater202642772066PubTator, text miningPubMed
Distinct functions of mammalian RAD51 paralogs in genome maintenance.Biochem Soc Trans202642682019PubTator, text miningPubMed
Impact of Multigene Panel Testing in High-Risk Uveal Melanoma Patients.Pigment Cell Melanoma Res202642415513PubTator, text miningPubMed
Saturation Genome Editing reveals the functional impact of RAD51D and XRCC2 variants.bioRxiv202642327150PubTator, text miningPubMed
Genetic Polymorphisms and Pesticide Exposure-Related Health Manifestations Among Grape Farmers in Maharashtra, India.Cureus202642281721PubTator, text miningPubMed
Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair.Occup Health (Auckl)202642169974PubTator, text miningPubMed
The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood.Am J Med Genet A202642071175PubTator, text miningPubMed
The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways.Nucleic Acids Res202642055550PubTator, text miningPubMed
Oxidative Stress, DNA Damage, DNA Repair Inhibition, and Apoptosis Induced by Lead and Cadmium Combined Exposure in TK6 Cells.Toxics202642043168PubTator, text miningPubMed

1 to 10 of 1,770

See all 1,770 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7516

GET https://conductscience.org/api/genes/v1/7516/patents?page=2