Gene · 7516
XRCC2: X-ray repair cross complementing 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. XRCC2: X-ray repair cross complementing 2. Genes, record 7516. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7516
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43543 | DNA repair protein XRCC2 | 280 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2024123008 A | 2024-09-10 | 9127 | O43543 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 219 | O43543 | Espacenet |
| US 11597924 B2 | 2023-03-07 | 60 | O43543 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 98041 | O43543 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 201012 | O43543 | Espacenet |
| WO 2021209517 A1 | 2021-10-21 | 15 | O43543 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 12683 | O43543 | Espacenet |
| JP 2020508335 A | 2020-03-19 | 219 | O43543 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 9127 | O43543 | Espacenet |
| KR 1020190120204 A | 2019-10-23 | 219 | O43543 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,114
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | XRCC2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 18 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 8 | 2025 |
| R35GM118026 | Mechanisms of Genome Integrity | 8 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 6 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 6 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 6 | 2025 |
| ZIACP010144 | Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes | 6 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 5 | 2025 |
1 to 10 of 1,114Source NIH's project files
See all 1,114 nih grantsPapers1,770
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer. | Diagnostics (Basel) | 2026 | 42793752 | PubTator, text mining | PubMed |
| Whole-blood total chromium and DNA repair variation in an occupational Cr(VI)-exposure setting: Pathway-resolved associations across complementary response biomarkers. | J Hazard Mater | 2026 | 42772066 | PubTator, text mining | PubMed |
| Distinct functions of mammalian RAD51 paralogs in genome maintenance. | Biochem Soc Trans | 2026 | 42682019 | PubTator, text mining | PubMed |
| Impact of Multigene Panel Testing in High-Risk Uveal Melanoma Patients. | Pigment Cell Melanoma Res | 2026 | 42415513 | PubTator, text mining | PubMed |
| Saturation Genome Editing reveals the functional impact of RAD51D and XRCC2 variants. | bioRxiv | 2026 | 42327150 | PubTator, text mining | PubMed |
| Genetic Polymorphisms and Pesticide Exposure-Related Health Manifestations Among Grape Farmers in Maharashtra, India. | Cureus | 2026 | 42281721 | PubTator, text mining | PubMed |
| Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair. | Occup Health (Auckl) | 2026 | 42169974 | PubTator, text mining | PubMed |
| The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood. | Am J Med Genet A | 2026 | 42071175 | PubTator, text mining | PubMed |
| The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways. | Nucleic Acids Res | 2026 | 42055550 | PubTator, text mining | PubMed |
| Oxidative Stress, DNA Damage, DNA Repair Inhibition, and Apoptosis Induced by Lead and Cadmium Combined Exposure in TK6 Cells. | Toxics | 2026 | 42043168 | PubTator, text mining | PubMed |
1 to 10 of 1,770
See all 1,770 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7516
GET https://conductscience.org/api/genes/v1/7516/patents?page=2