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Gene · 7531

YWHAE: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. YWHAE: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon. Genes, record 7531. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7531

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Gene

Symbol
YWHAE
HGNC
Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
HGNC
NCBI Gene ID
7531
NCBI Gene
HGNC ID
HGNC:12851
HGNC
Ensembl
ENSG00000108953
NCBI Gene
Aliases
14-3-3E, FLJ45465, HEL2, KCIP-1, MDCR, MDS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P6225814-3-3 protein epsilon25511Ensembl, GeneID, HGNC

Source UniProt

Patents141

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805736 A22026-09-161P62258Espacenet
JP 2026004568 A2026-01-1468775P62258Espacenet
EP 4650780 A22025-11-192341P62258Espacenet
JP 2025517970 A2025-06-122341P62258Espacenet
US 12275779 B22025-04-1540P62258Espacenet
EP 4519435 A22025-03-1230P62258Espacenet
US 11708396 B22023-07-251323P62258Espacenet
US 11686737 B22023-06-274P62258Espacenet
JP 2023064789 A2023-05-1287P62258Espacenet
WO 2023074712 A2023-05-0433P62258Espacenet

1 to 10 of 141

See all 141 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,621

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleYWHAE papersNewest fiscal year
P30CA008748Cancer Center Support Grant332025
P50CA217694SPORE in Soft Tissue Sarcoma102025
P30CA016672Cancer Center Support Grant92025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers52025
P20GM139762Translational Hearing Center42025
P30ES006694Southwest Environmental Health Sciences Center42025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30DK034854Integrated Epithelial and Muscosal Biology32025

1 to 10 of 1,621Source NIH's project files

See all 1,621 nih grants

Papers2,658

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype.J Immunother Cancer202642716706PubTator, text miningPubMed
Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score.J Med Genet202642697718PubTator, text miningPubMed
Isoform-resolved 14-3-3/YWHA networks in colorectal cancer: phospho-adaptor mechanisms, biomarker contexts and therapeutic opportunities.Front Oncol202642688965PubTator, text miningPubMed
Transcriptomic Profiling of the Effects of DDR1 in Breast and Ovarian Cancer to Understand the Association Between DDR1 Expression and Patient Survival.Genes (Basel)202642510800PubTator, text miningPubMed
Keratin 16 puts the brakes on type I interferon signalling.Trends Mol Med202642476866PubTator, text miningPubMed
Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.Dig Dis Sci202642400718PubTator, text miningPubMed
Novel YWHAE-NTRK3 fusion in a pediatric glioma.J Neuropathol Exp Neurol202642359936PubTator, text miningPubMed
Nuclear receptor subfamily 2 group F member 2 transcriptionally activates 14-3-3 epsilon to promote diffuse large B-cell lymphoma progression.Cytotechnology202642040327PubTator, text miningPubMed
MiR-4261 targeted YWHAE/CAST/GPX1 impairs the calcium regulatory function of PMCA4 in erythrocytes of myeloma.Indian J Pathol Microbiol202641983776PubTator, text miningPubMed
Miller-Dieker Syndrome: Genetic Etiology, Neurocognitive Impact, and Clinical Implications in a Neuronal Migration Disorder.Dev Neuropsychol202641979906PubTator, text miningPubMed

1 to 10 of 2,658

See all 2,658 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7531

GET https://conductscience.org/api/genes/v1/7531/patents?page=2