Gene · 7531
YWHAE: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. YWHAE: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon. Genes, record 7531. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7531
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P62258 | 14-3-3 protein epsilon | 255 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents141
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805736 A2 | 2026-09-16 | 1 | P62258 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 68775 | P62258 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2341 | P62258 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2341 | P62258 | Espacenet |
| US 12275779 B2 | 2025-04-15 | 40 | P62258 | Espacenet |
| EP 4519435 A2 | 2025-03-12 | 30 | P62258 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1323 | P62258 | Espacenet |
| US 11686737 B2 | 2023-06-27 | 4 | P62258 | Espacenet |
| JP 2023064789 A | 2023-05-12 | 87 | P62258 | Espacenet |
| WO 2023074712 A | 2023-05-04 | 33 | P62258 | Espacenet |
1 to 10 of 141
See all 141 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,621
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | YWHAE papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 33 | 2025 |
| P50CA217694 | SPORE in Soft Tissue Sarcoma | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| ZIABC005708 | Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers | 5 | 2025 |
| P20GM139762 | Translational Hearing Center | 4 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 4 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 3 | 2025 |
1 to 10 of 1,621Source NIH's project files
See all 1,621 nih grantsPapers2,658
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype. | J Immunother Cancer | 2026 | 42716706 | PubTator, text mining | PubMed |
| Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score. | J Med Genet | 2026 | 42697718 | PubTator, text mining | PubMed |
| Isoform-resolved 14-3-3/YWHA networks in colorectal cancer: phospho-adaptor mechanisms, biomarker contexts and therapeutic opportunities. | Front Oncol | 2026 | 42688965 | PubTator, text mining | PubMed |
| Transcriptomic Profiling of the Effects of DDR1 in Breast and Ovarian Cancer to Understand the Association Between DDR1 Expression and Patient Survival. | Genes (Basel) | 2026 | 42510800 | PubTator, text mining | PubMed |
| Keratin 16 puts the brakes on type I interferon signalling. | Trends Mol Med | 2026 | 42476866 | PubTator, text mining | PubMed |
| Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis. | Dig Dis Sci | 2026 | 42400718 | PubTator, text mining | PubMed |
| Novel YWHAE-NTRK3 fusion in a pediatric glioma. | J Neuropathol Exp Neurol | 2026 | 42359936 | PubTator, text mining | PubMed |
| Nuclear receptor subfamily 2 group F member 2 transcriptionally activates 14-3-3 epsilon to promote diffuse large B-cell lymphoma progression. | Cytotechnology | 2026 | 42040327 | PubTator, text mining | PubMed |
| MiR-4261 targeted YWHAE/CAST/GPX1 impairs the calcium regulatory function of PMCA4 in erythrocytes of myeloma. | Indian J Pathol Microbiol | 2026 | 41983776 | PubTator, text mining | PubMed |
| Miller-Dieker Syndrome: Genetic Etiology, Neurocognitive Impact, and Clinical Implications in a Neuronal Migration Disorder. | Dev Neuropsychol | 2026 | 41979906 | PubTator, text mining | PubMed |
1 to 10 of 2,658
See all 2,658 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7531
GET https://conductscience.org/api/genes/v1/7531/patents?page=2