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ZAP70: zeta chain of T cell receptor associated protein kinase 70

1 protein, 180 patents, 0 drugs, 0 trials, 4,115 NIH grants and 7,694 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolZAP70HGNC
Namezeta chain of T cell receptor associated protein kinase 70HGNC
NCBI Gene ID7535NCBI Gene
HGNC IDHGNC:12858HGNC
EnsemblENSG00000115085NCBI Gene
AliasesADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43403Tyrosine-protein kinase ZAP-7061915Ensembl, GeneID, HGNCUniProt

Patents 180

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4752227 A22026-06-0336P43403Espacenet
JP 2026054469 A2026-03-2652P43403Espacenet
JP 2026004568 A2026-01-1470101P43403Espacenet
JP 2025541700 A2025-12-23153P43403Espacenet
JP 2025185029 A2025-12-18368P43403Espacenet
EP 4661970 A12025-12-1762170P43403Espacenet
WO 2025252547 A12025-12-11159P43403Espacenet
EP 4660322 A12025-12-10159P43403Espacenet
US 12478626 B22025-11-251P43403Espacenet
WO 2025235862 A12025-11-1371P43403Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4115

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1172,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR472,025NIH's project files
P30CA008748Cancer Center Support Grant362,025NIH's project files
ZIABC010304Biochemical Basis of T Cell Activation232,025NIH's project files
P30CA016058Cancer Center Support Grant182,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant152,025NIH's project files
ZIAHL002346Tumor microenvironment in CLL and MCL: pathogenesis, targets, and therapy142,025NIH's project files
P30CA086862Cancer Center Support Grant132,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged122,025NIH's project files
ZICBC010978Confocal Core for the Laboratory of Cellular and Molecular Biology122,025NIH's project files

Papers 7694

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42805448PubTator, text miningPubMed
42758196PubTator, text miningPubMed
42728269PubTator, text miningPubMed
42701720PubTator, text miningPubMed
42658691PubTator, text miningPubMed
42650839PubTator, text miningPubMed
42607060PubTator, text miningPubMed
42554661PubTator, text miningPubMed
42536735PubTator, text miningPubMed
42519578PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license