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CA1: carbonic anhydrase 1

1 protein, 90 patents, 8 drugs, 84 trials, 2,434 NIH grants and 4,999 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCA1HGNC
Namecarbonic anhydrase 1HGNC
NCBI Gene ID759NCBI Gene
HGNC IDHGNC:1368HGNC
EnsemblENSG00000133742NCBI Gene
AliasesCA-I, CAB, Car1, HEL-S-11NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00915Carbonic anhydrase 126156Ensembl, GeneID, HGNCUniProt

Patents 90

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439998P00915Espacenet
JP 2026004568 A2026-01-1439999P00915Espacenet
JP 2026004568 A2026-01-1440000P00915Espacenet
JP 2026004568 A2026-01-1440008P00915Espacenet
JP 2026004568 A2026-01-1440010P00915Espacenet
JP 2026004568 A2026-01-1440011P00915Espacenet
JP 2025062604 A2025-04-1411698P00915Espacenet
JP 2025062604 A2025-04-1411704P00915Espacenet
JP 2025062604 A2025-04-1411710P00915Espacenet
JP 2025062604 A2025-04-1411715P00915Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETAZOLAMIDECHEMBL20Carbonic anhydrase I inhibitorINHIBITORChEMBL
ACETAZOLAMIDE SODIUMCHEMBL1200814Carbonic anhydrase I inhibitorINHIBITORChEMBL
DICHLORPHENAMIDECHEMBL17Carbonic anhydrase I inhibitorINHIBITORChEMBL
ETHOXZOLAMIDECHEMBL18Carbonic anhydrase inhibitorINHIBITORChEMBL
METHAZOLAMIDECHEMBL19Carbonic anhydrase I inhibitorINHIBITORChEMBL
METHOCARBAMOLCHEMBL1201117Carbonic anhydrase I inhibitorINHIBITORChEMBL
POLMACOXIBCHEMBL166863Carbonic anhydrase I inhibitorINHIBITORChEMBL
SULTHIAMECHEMBL328560Carbonic anhydrase inhibitorINHIBITORChEMBL

Trials 84

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07517068ACETAZOLAMIDEEARLY_PHASE1ClinicalTrials.gov
NCT07469722ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07372040ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06981234ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06945848ACETAZOLAMIDEClinicalTrials.gov
NCT06919744ACETAZOLAMIDEClinicalTrials.gov
NCT06783166ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT06776432ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06535529ACETAZOLAMIDEPHASE3ClinicalTrials.gov
NCT06521476ACETAZOLAMIDEPHASE2ClinicalTrials.gov

NIH grants 2434

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study62,025NIH's project files
P30AG066519The Alzheimer's Disease Research Center at the University of California, Irvine62,025NIH's project files
P30CA008748Cancer Center Support Grant52,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program52,025NIH's project files
P30DK036836Diabetes Research Center52,025NIH's project files
P51OD011107California National Primate Research Center52,025NIH's project files
R01AI145870Development of vaccination strategies to elicit broadly protective immunity against influenza52,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award52,025NIH's project files
P30AG066444Alzheimer's Disease Research Center42,025NIH's project files
P51OD011104Tulane National Primate Research Center42,025NIH's project files

Papers 4999

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42747343PubTator, text miningPubMed
42745684PubTator, text miningPubMed
42710750PubTator, text miningPubMed
42653817PubTator, text miningPubMed
42638586PubTator, text miningPubMed
42591023PubTator, text miningPubMed
42563225PubTator, text miningPubMed
42511717PubTator, text miningPubMed
42486551PubTator, text miningPubMed
42471764PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license