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CA2: carbonic anhydrase 2

1 protein, 136 patents, 11 drugs, 323 trials, 7,275 NIH grants and 15,113 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCA2HGNC
Namecarbonic anhydrase 2HGNC
NCBI Gene ID760NCBI Gene
HGNC IDHGNC:1373HGNC
EnsemblENSG00000104267NCBI Gene
AliasesCA-II, CAC, CAII, Car2, HEL-76, HEL-S-282NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00918Carbonic anhydrase 22601,243Ensembl, GeneID, HGNCUniProt

Patents 136

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509481 A2026-03-199P00918Espacenet
JP 2026004568 A2026-01-1440012P00918Espacenet
JP 2025185029 A2025-12-186P00918Espacenet
KR 1020250164239 A2025-11-249P00918Espacenet
EP 4641202 A22025-10-294685P00918Espacenet
WO 2025186446 A12025-09-1238P00918Espacenet
EP 4613860 A12025-09-1038P00918Espacenet
JP 2025122052 A2025-08-205P00918Espacenet
JP 2025100715 A2025-07-031P00918Espacenet
WO 2025144887 A12025-07-031P00918Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETAZOLAMIDECHEMBL20Carbonic anhydrase II inhibitorINHIBITORChEMBL
ACETAZOLAMIDE SODIUMCHEMBL1200814Carbonic anhydrase II inhibitorINHIBITORChEMBL
BRINZOLAMIDECHEMBL220491Carbonic anhydrase II inhibitorINHIBITORChEMBL
DICHLORPHENAMIDECHEMBL17Carbonic anhydrase II inhibitorINHIBITORChEMBL
DORZOLAMIDECHEMBL218490Carbonic anhydrase II inhibitorINHIBITORChEMBL
DORZOLAMIDE HYDROCHLORIDECHEMBL1201162Carbonic anhydrase II inhibitorINHIBITORChEMBL
ETHOXZOLAMIDECHEMBL18Carbonic anhydrase inhibitorINHIBITORChEMBL
METHAZOLAMIDECHEMBL19Carbonic anhydrase II inhibitorINHIBITORChEMBL
POLMACOXIBCHEMBL166863Carbonic anhydrase II inhibitorINHIBITORChEMBL
SULTHIAMECHEMBL328560Carbonic anhydrase inhibitorINHIBITORChEMBL

Trials 323

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07517068ACETAZOLAMIDEEARLY_PHASE1ClinicalTrials.gov
NCT07469722ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT07372040ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06981234ACETAZOLAMIDEPHASE2ClinicalTrials.gov
NCT06945848ACETAZOLAMIDEClinicalTrials.gov
NCT06919744ACETAZOLAMIDEClinicalTrials.gov
NCT06883123BRINZOLAMIDEPHASE4ClinicalTrials.gov
NCT06783166ACETAZOLAMIDEPHASE2/PHASE3ClinicalTrials.gov

NIH grants 7275

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant162,025NIH's project files
ZIAES100221Mechanisms Of Synaptic Plasticity In The Adult And Developing Nervous System142,025NIH's project files
P30CA016672Cancer Center Support Grant112,025NIH's project files
R01DE017102TRPC1, Calcium, and Saliva Secretion112,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant92,025NIH's project files
P30DK019525University of Pennsylvania Diabetes Research Center82,025NIH's project files
P30DK036836Diabetes Research Center82,025NIH's project files
R01GM049758Structure and Function of Metalloenzymes82,025NIH's project files
R01HL092097Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII82,025NIH's project files
R01MH104602Control of CA2 by its cortico-hippocampal inputs and local inhibition in social information processing and learning82,025NIH's project files

Papers 15113

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820787PubTator, text miningPubMed
42811799PubTator, text miningPubMed
42808165PubTator, text miningPubMed
42807979PubTator, text miningPubMed
42802557PubTator, text miningPubMed
42794739PubTator, text miningPubMed
42787432PubTator, text miningPubMed
42784032PubTator, text miningPubMed
42777704PubTator, text miningPubMed
42766338PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license