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Gene · 761

CA3: carbonic anhydrase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CA3: carbonic anhydrase 3. Genes, record 761. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/761

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Gene

Symbol
CA3
HGNC
Name
carbonic anhydrase 3
HGNC
NCBI Gene ID
761
NCBI Gene
HGNC ID
HGNC:1374
HGNC
Ensembl
ENSG00000164879
NCBI Gene
Aliases
CAIII, Car3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07451Carbonic anhydrase 32605Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440013P07451Espacenet
JP 2025062604 A2025-04-1411720P07451Espacenet
US 11446398 B22022-09-2011720P07451Espacenet
JP 2022524081 A2022-04-27114691P07451Espacenet
US 11078247 B22021-08-031479P07451Espacenet
JP 2019054813 A2019-04-11220448P07451Espacenet
US 9952224 B22018-04-24249P07451Espacenet
JP 2017121241 A2017-07-13220448P07451Espacenet
WO 2015174544 A2015-11-19147P07451Espacenet
JP 2015516143 A2015-06-08220448P07451Espacenet

1 to 10 of 18

See all 18 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ETHOXZOLAMIDECHEMBL18Carbonic anhydrase inhibitorINHIBITORChEMBL
SULTHIAMECHEMBL328560Carbonic anhydrase inhibitorINHIBITORChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05885646SULTHIAMEClinicalTrials.gov
NCT05236842SULTHIAMEPHASE2ClinicalTrials.gov

NIH grants1,323

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCA3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P01AG009973Cognition & Hippocampal/Cortical Systems in Aging62025
R01NS076856Representation of spatiotemporal information in human episodic memory and navigation62025
P30CA008748Cancer Center Support Grant42025
R01AG003376Neurobehavioral Relations in Senescent Hippocampus42025
R01AG053555Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN Cohort42025
T32AG027668Research Training in Age-Related Cognitive Disorders42025
U54NS092091Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)42025
P30AG066519The Alzheimer's Disease Research Center at the University of California, Irvine32025
R01MH107512Development of Memory Networks in Children32025

1 to 10 of 1,323Source NIH's project files

See all 1,323 nih grants

Papers2,219

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mental Scene and Memory Construction and the Hippocampus.Hippocampus202642806524PubTator, text miningPubMed
Structural insights into target detection by the Serratia type III CRISPR complex and its deployment in SNP identifications.J Biol Chem202642772556PubTator, text miningPubMed
Correction for Miguel-López et al., Transformations of the spatial activity manifold convey aversive information in CA3.Proc Natl Acad Sci U S A202642766758PubTator, text miningPubMed
Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems.PLoS Biol202642743106PubTator, text miningPubMed
From operating room to circuit mechanisms: Clinical basic science partnerships as a strategic model for human neuroscience.Epilepsia202642663527PubTator, text miningPubMed
Design, synthesis, biological evaluation, and in silico studies of novel pyrrolidine based hybrids bearing indole, chromone, and benzoylthiourea pharmacophores as multitarget hCA and AChE inhibitors.Comput Biol Chem202642659947PubTator, text miningPubMed
Development sculpts dense neural circuits to enhance memory capacity.Trends Neurosci202642608247PubTator, text miningPubMed
Correction: Glutamate imaging reveals multiple sites of stochastic release in the CA3 giant mossy fiber boutons.Front Cell Neurosci202642602226PubTator, text miningPubMed
Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole-Based Thiosemicarbazones as Potential AChE and CA I-II Inhibitors.Arch Pharm (Weinheim)202642592691PubTator, text miningPubMed
Developmentally defined subcircuits in the hippocampus support spatial learning.Neuron202642586057PubTator, text miningPubMed

1 to 10 of 2,219

See all 2,219 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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