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Gene · 7706

TRIM25: tripartite motif containing 25

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIM25: tripartite motif containing 25. Genes, record 7706. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7706

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Gene

Symbol
TRIM25
HGNC
Name
tripartite motif containing 25
HGNC
NCBI Gene ID
7706
NCBI Gene
HGNC ID
HGNC:12932
HGNC
Ensembl
ENSG00000121060
NCBI Gene
Aliases
EFP, RNF147, Z147, ZNF147
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14258E3 ubiquitin/ISG15 ligase TRIM2563010Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468000Q14258Espacenet
JP 2026004568 A2026-01-1468001Q14258Espacenet
EP 4650780 A22025-11-195523Q14258Espacenet
JP 2025517970 A2025-06-125523Q14258Espacenet
JP 2024161501 A2024-11-1950Q14258Espacenet
KR 1020240108531 A2024-07-0950Q14258Espacenet
US 11542500 B22023-01-0350Q14258Espacenet
US 11446398 B22022-09-2092348Q14258Espacenet
US 11446398 B22022-09-2092349Q14258Espacenet
JP 2022524081 A2022-04-27195319Q14258Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,417

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIM25 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P01CA019014Viral Oncogenesis, Latency, and Replication52025
P01CA116087H. pylori-induced Inflammation and Gastric Cancer52025
P30CA008748Cancer Center Support Grant52025
R01AI158704Functional analysis of host and viral determinants for ZAP inhibition52025
R37AI087846Regulation of Host Innate Immunity Against Viral Infection52025
T32AI060549Biodefense Training Program52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P51OD011132Emory National Primate Research Center42025
ZIAHD001310Gene Regulation In The Immune System42025

1 to 10 of 1,417Source NIH's project files

See all 1,417 nih grants

Papers2,924

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The response mechanism of mandarin fish (Siniperca chuatsi) astrocyte-like cells to SCRV infection: Insights from Transcriptome Sequencing.Fish Shellfish Immunol202642815866PubTator, text miningPubMed
KAT5-mediated HSPA1A lactylation drives immunotherapy resistance by inhibiting STAT1 degradation in esophageal squamous cell carcinoma.Oncogene202642786271PubTator, text miningPubMed
Integrated bioinformatics analysis, machine learning, and experimental validation reveal that ACSL1 drives myocardial ischemia reperfusion injury via ferroptosis.J Bioenerg Biomembr202642782425PubTator, text miningPubMed
Single-cell profiling reveals context-dependent immune regulation shared by sepsis and systemic lupus erythematosus.Front Immunol202642755868PubTator, text miningPubMed
Guanylate-binding protein 2 (GBP2) drives pancreatic cancer cell proliferation by promoting cell cycle progression via the SP1/SKP2/P27 axis.J Transl Med202642750038PubTator, text miningPubMed
Splenic transcriptomic profiling reveals innate immune responses and RIG-I-like receptor signaling in goslings infected with goose astrovirus.Front Vet Sci202642718786PubTator, text miningPubMed
The TUBA1B-G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression.Adv Sci (Weinh)202642702897PubTator, text miningPubMed
TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7-driven ENO1 deubiquitination during intervertebral disc degeneration.Clin Transl Med202642671335PubTator, text miningPubMed
LncRNA-miRNA-mRNA Regulatory Network Reveals Potential Immune Responses in Larval Tomato Hind (Cephalopholis sonnerati) Infected with RGNNV.Biology (Basel)202642651684PubTator, text miningPubMed
EF-P-Mediated Enhancement of Protein Synthesis: Cyclic Dipeptide Incorporation Using Mono- and Bisaminoacylated tRNAs.ACS Chem Biol202642617067PubTator, text miningPubMed

1 to 10 of 2,924

See all 2,924 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7706

GET https://conductscience.org/api/genes/v1/7706/patents?page=2