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Gene · 773

CACNA1A: calcium voltage-gated channel subunit alpha1 A

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. CACNA1A: calcium voltage-gated channel subunit alpha1 A. Genes, record 773. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/773

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
CACNA1A
HGNC
Name
calcium voltage-gated channel subunit alpha1 A
HGNC
NCBI Gene ID
773
NCBI Gene
HGNC ID
HGNC:1388
HGNC
Ensembl
ENSG00000141837
NCBI Gene
Aliases
APCA, BI, CACNL1A4, CAV2.1, Cav2.1, DEE42, DEE42A, DEE42B, EA2, EIEE42, FHM, HPCA, MHP, MHP1, SCA6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00555Voltage-dependent P/Q-type calcium channel subunit alpha-1A2,5064Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439664O00555Espacenet
EP 4641201 A22025-10-297820O00555Espacenet
JP 2025529142 A2025-09-04687O00555Espacenet
US 12371689 B22025-07-29687O00555Espacenet
JP 2025517969 A2025-06-127820O00555Espacenet
JP 2025062604 A2025-04-1410767O00555Espacenet
JP 2025032204 A2025-03-1125450O00555Espacenet
EP 4461818 A22024-11-1325450O00555Espacenet
JP 2023548973 A2023-11-21234O00555Espacenet
JP 2023058610 A2023-04-2525450O00555Espacenet

1 to 10 of 20

See all 20 patents

Drugs12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
ELPETRIGINECHEMBL29919Voltage-gated P/Q-type calcium channel alpha-1A subunit blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
PHLOROGLUCINOLCHEMBL473159Voltage-gated calcium channel blockerBLOCKERChEMBL
PREGABALINCHEMBL1059Voltage-gated calcium channel modulatorMODULATORChEMBL
SULOCTIDILCHEMBL404849Voltage-gated calcium channel blockerBLOCKERChEMBL

1 to 10 of 12

See all 12 drugs

Trials370

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,357

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
R01NS124854Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential Tremor92025
R01EY020928Genetic and Environmental Risk Factors for Exfoliation Syndrome and Glaucoma72025
R01NS027699Molecular Studies of Spinocerebellar Ataxia Type 172025
R01NS055251Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors72025
P30ES009089Center for Environmental Health in Northern Manhattan62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30CA016672Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center52025
R01NS083898Molecular Dissection of Active Zone Functions in Neurotransmitter Release52025

1 to 10 of 2,357Source NIH's project files

See all 2,357 nih grants

Papers4,421

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42806408PubTator, text miningPubMed
42802208PubTator, text miningPubMed
42688563PubTator, text miningPubMed
42677125PubTator, text miningPubMed
42650055PubTator, text miningPubMed
42633474PubTator, text miningPubMed
42632018PubTator, text miningPubMed
42575091PubTator, text miningPubMed
42574932PubTator, text miningPubMed
42547258PubTator, text miningPubMed

1 to 10 of 4,421

See all 4,421 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/773

GET https://conductscience.org/api/genes/v1/773/patents