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Gene · 774

CACNA1B: calcium voltage-gated channel subunit alpha1 B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1B: calcium voltage-gated channel subunit alpha1 B. Genes, record 774. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/774

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Gene

Symbol
CACNA1B
HGNC
Name
calcium voltage-gated channel subunit alpha1 B
HGNC
NCBI Gene ID
774
NCBI Gene
HGNC ID
HGNC:1389
HGNC
Ensembl
ENSG00000148408
NCBI Gene
Aliases
BIII, CACNL1A5, CACNN, Cav2.2, DYT23, NEDNEH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q00975Voltage-dependent N-type calcium channel subunit alpha-1B2,3397Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439659Q00975Espacenet
EP 4641201 A22025-10-299190Q00975Espacenet
JP 2025529142 A2025-09-04688Q00975Espacenet
US 12371689 B22025-07-29688Q00975Espacenet
JP 2025517969 A2025-06-129190Q00975Espacenet
JP 2025062604 A2025-04-1410765Q00975Espacenet
JP 2025032204 A2025-03-1125477Q00975Espacenet
EP 4461818 A22024-11-1325477Q00975Espacenet
US 11795509 B22023-10-244Q00975Espacenet
JP 2023058610 A2023-04-2525477Q00975Espacenet

1 to 10 of 43

See all 43 patents

Drugs18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
CNV2197944CHEMBL5314401Voltage-gated N-type calcium channel alpha-1B subunit blockerBLOCKERChEMBL
ELPETRIGINECHEMBL29919Voltage-gated N-type calcium channel alpha-1B subunit blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
LEVETIRACETAMCHEMBL1286Voltage-gated N-type calcium channel alpha-1B subunit blockerBLOCKERChEMBL
PHLOROGLUCINOLCHEMBL473159Voltage-gated calcium channel blockerBLOCKERChEMBL

1 to 10 of 18

See all 18 drugs

Trials512

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,284

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1B papersNewest fiscal year
P30CA054174Mays Cancer Center at UT Health SA212025
R01NS055251Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors182025
R01HL121253L-type channel trafficking and modulation in heart72025
P30CA013696Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant42025
R01EY026817Calcium channels in retinal photoreceptors42025
ZIANS003164Readout of the tubulin code by cellular effectors42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30DK020593Vanderbilt Diabetes Research Center32025
R01HL165259Central role of Caspase-8 in control of host tolerance and resistance mechanisms in pulmonary macrophage populations during severe respiratory infections32025

1 to 10 of 1,284Source NIH's project files

See all 1,284 nih grants

Papers1,947

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin.Int J Mol Sci202642794641PubTator, text miningPubMed
Macro-Micro structural integration for characterizing severity-related structural alterations in mild cognitive impairment.Neuroimage Clin202642771911PubTator, text miningPubMed
Correction to "The Transmitter Release-Site CaV2.2 Channel Cluster is Linked to an Endocytosis Coat Protein Complex".Eur J Neurosci202642689417PubTator, text miningPubMed
Structural rigidity of the I-II loop couples CaV β anchoring to CaV2.2 gating modes.Proc Natl Acad Sci U S A202642485390PubTator, text miningPubMed
A human-derived Pseudorabies virus isolate induces Cav2.2-sensitive Ca2+ influx and JNK-associated retinal epithelial injury.Microbiol Spectr202642461027PubTator, text miningPubMed
Synaptic Ca2+ channels and neurexins are linked through direct and indirect binding complexes.Sci Rep202642457853PubTator, text miningPubMed
Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512-2).Basic Clin Pharmacol Toxicol202642383434PubTator, text miningPubMed
Targeting Cav2.2 channels for pain management: challenges, innovations, and future perspectives.Biochem Pharmacol202642361918PubTator, text miningPubMed
Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics.Neuropharmacology202642288194PubTator, text miningPubMed
Nociceptor-enriched CAPS1 isoform couples to CaV2.2 channels and underlies inflammatory pain hypersensitivity.bioRxiv202642244681PubTator, text miningPubMed

1 to 10 of 1,947

See all 1,947 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/774

GET https://conductscience.org/api/genes/v1/774/patents?page=2