ConductScience.org, home

Library / Genes

CACNA1C: calcium voltage-gated channel subunit alpha1 C

1 protein, 10 patents, 45 drugs, 965 trials, 4,347 NIH grants and 6,069 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCACNA1CHGNC
Namecalcium voltage-gated channel subunit alpha1 CHGNC
NCBI Gene ID775NCBI Gene
HGNC IDHGNC:1390HGNC
EnsemblENSG00000151067NCBI Gene
AliasesCACH2, CACN2, CACNA1C-IT2, CACNL1A1, CCHL1A1, Ca(V)1.2, CaV1.2, Cav1.2, LQT8, NEDHLSS, TS, TS. LQT8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13936Voltage-dependent L-type calcium channel subunit alpha-1C2,22133Ensembl, GeneID, HGNCUniProt

Patents 10

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094314 A2026-06-09106Q13936Espacenet
JP 2026021360 A2026-02-10134Q13936Espacenet
JP 2025529142 A2025-09-04689Q13936Espacenet
US 12371689 B22025-07-29689Q13936Espacenet
JP 2025041709 A2025-03-26115Q13936Espacenet
JP 2025023947 A2025-02-19106Q13936Espacenet
JP 2025024092 A2025-02-19134Q13936Espacenet
JP 2022520437 A2022-03-30121Q13936Espacenet
JP 2022513426 A2022-02-08148Q13936Espacenet
JP 2022513339 A2022-02-07106Q13936Espacenet

Drugs 45

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMLODIPINECHEMBL1491Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BENZOATECHEMBL4594262Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BESYLATECHEMBL1200402Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE MALEATECHEMBL1200984Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
AZD1305CHEMBL3545169Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AZELNIDIPINECHEMBL1275868Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BARNIDIPINECHEMBL2103761Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BENIDIPINECHEMBL2074972Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL

Trials 965

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606638PREGABALINClinicalTrials.gov
NCT07603037NICARDIPINEClinicalTrials.gov
NCT07598474PREGABALINClinicalTrials.gov
NCT07564726AMLODIPINEPHASE3ClinicalTrials.gov
NCT07458880AMLODIPINEClinicalTrials.gov
NCT07448506NIFEDIPINEPHASE3ClinicalTrials.gov
NCT07429734GABAPENTINPHASE3ClinicalTrials.gov
NCT07420166VERAPAMIL HYDROCHLORIDEClinicalTrials.gov
NCT07382921PREGABALINClinicalTrials.gov
NCT07364201NICARDIPINEClinicalTrials.gov

NIH grants 4347

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AG055357Dysregulation of Cav1.2 by beta amyloid peptide162,025NIH's project files
R01HL121253L-type channel trafficking and modulation in heart132,025NIH's project files
T32HL086350Training Program in Basic and Translational Cardiovascular Science132,025NIH's project files
R01HL146149Phosphorylation-dependent regulation of calcium channels by macromolecular complexes112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
R01AG063796Molecular choreography and trafficking in the aging myocardium102,025NIH's project files
R01HL076485Engineering Vascularized Cardiac Muscle102,025NIH's project files
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation92,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling82,025NIH's project files
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation82,025NIH's project files

Papers 6069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818195PubTator, text miningPubMed
42817756PubTator, text miningPubMed
42808165PubTator, text miningPubMed
42780784PubTator, text miningPubMed
42755451PubTator, text miningPubMed
42737842PubTator, text miningPubMed
42733558PubTator, text miningPubMed
42728318PubTator, text miningPubMed
42684683PubTator, text miningPubMed
42663306PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license