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Gene · 776

CACNA1D: calcium voltage-gated channel subunit alpha1 D

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1D: calcium voltage-gated channel subunit alpha1 D. Genes, record 776. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/776

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Gene

Symbol
CACNA1D
HGNC
Name
calcium voltage-gated channel subunit alpha1 D
HGNC
NCBI Gene ID
776
NCBI Gene
HGNC ID
HGNC:1391
HGNC
Ensembl
ENSG00000157388
NCBI Gene
Aliases
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01668Voltage-dependent L-type calcium channel subunit alpha-1D2,1616Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439641Q01668Espacenet
EP 4641201 A22025-10-292924Q01668Espacenet
JP 2025529142 A2025-09-04690Q01668Espacenet
US 12371689 B22025-07-29690Q01668Espacenet
JP 2025517969 A2025-06-122924Q01668Espacenet
JP 2025062604 A2025-04-1410749Q01668Espacenet
JP 2025032204 A2025-03-1125484Q01668Espacenet
EP 4461818 A22024-11-1325484Q01668Espacenet
US 12077582 B22024-09-036Q01668Espacenet
JP 2023058610 A2023-04-2525484Q01668Espacenet

1 to 10 of 27

See all 27 patents

Drugs45

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMLODIPINECHEMBL1491Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BENZOATECHEMBL4594262Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BESYLATECHEMBL1200402Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE MALEATECHEMBL1200984Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
AZD1305CHEMBL3545169Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AZELNIDIPINECHEMBL1275868Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BARNIDIPINECHEMBL2103761Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BENIDIPINECHEMBL2074972Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL

1 to 10 of 45

See all 45 drugs

Trials965

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,680

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1D papersNewest fiscal year
U54GM115428Mississippi Center for Clinical and Translational Research192025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025
R01DK043140Mechanisms Leading to Adrenal Zonation92025
UL1TR001863Yale Clinical and Translational Science Award82025
P30DK020593Vanderbilt Diabetes Research Center62025
R01EY026817Calcium channels in retinal photoreceptors62025
R01HL085844Functional interactions of cardiac ion channels62025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation62025
T32HL086350Training Program in Basic and Translational Cardiovascular Science62025
P30CA008748Cancer Center Support Grant52025

1 to 10 of 1,680Source NIH's project files

See all 1,680 nih grants

Papers2,356

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated bioinformatics analysis of chromosomal deletion regions in glioblastoma identifies key genes linked to GABA(A) receptor signaling.J Biomol Struct Dyn202642752294PubTator, text miningPubMed
Emerging genetics of sleep and circadian disorders.Curr Opin Pediatr202642750652PubTator, text miningPubMed
Molecular basis for a Ca2+ binding hierarchy in the EF-hand motifs of CaBP2.J Biol Chem202642648358PubTator, text miningPubMed
Splicing Factor SF3B2 Regulates Cardiomyocyte Calcium Handling Through Alternative Splicing of Cardiac Ion Channel Genes.bioRxiv202642619934PubTator, text miningPubMed
Rare germline variants in canonical and candidate genes in apparently sporadic bilateral primary aldosteronism.J Endocr Soc202642577001PubTator, text miningPubMed
Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling.Proc Natl Acad Sci U S A202642546191PubTator, text miningPubMed
[Primary aldosteronism as an independent factor of kidney damage. Potential therapeutic strategies and research prospects].Probl Endokrinol (Mosk)202642545319PubTator, text miningPubMed
Coordinated Transcriptional Repression of CAV1 and CAV2 in Thoracic Aortic Aneurysm: A microRNA Regulatory Network Analysis.Genes (Basel)202642510867PubTator, text miningPubMed
Caveolae in cancer: mechanochemical signaling in tumor progression, immunity, and therapy.Cell Commun Signal202642482076PubTator, text miningPubMed
Impact of CaV1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer.Int J Mol Sci202642449938PubTator, text miningPubMed

1 to 10 of 2,356

See all 2,356 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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