Gene · 776
CACNA1D: calcium voltage-gated channel subunit alpha1 D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA1D: calcium voltage-gated channel subunit alpha1 D. Genes, record 776. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/776
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q01668 | Voltage-dependent L-type calcium channel subunit alpha-1D | 2,161 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39641 | Q01668 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2924 | Q01668 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 690 | Q01668 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 690 | Q01668 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2924 | Q01668 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10749 | Q01668 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25484 | Q01668 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 25484 | Q01668 | Espacenet |
| US 12077582 B2 | 2024-09-03 | 6 | Q01668 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 25484 | Q01668 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs45
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMLODIPINE | CHEMBL1491 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| AMLODIPINE BENZOATE | CHEMBL4594262 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| AMLODIPINE BESYLATE | CHEMBL1200402 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| AMLODIPINE MALEATE | CHEMBL1200984 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| AZD1305 | CHEMBL3545169 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| AZELNIDIPINE | CHEMBL1275868 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| BARNIDIPINE | CHEMBL2103761 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| BENIDIPINE | CHEMBL2074972 | Voltage-gated L-type calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
1 to 10 of 45
See all 45 drugsTrials965
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07603037 | NICARDIPINE | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07564726 | AMLODIPINE | PHASE3 | ClinicalTrials.gov | |
| NCT07458880 | AMLODIPINE | ClinicalTrials.gov | ||
| NCT07448506 | NIFEDIPINE | PHASE3 | ClinicalTrials.gov | |
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07420166 | VERAPAMIL HYDROCHLORIDE | ClinicalTrials.gov | ||
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07364201 | NICARDIPINE | ClinicalTrials.gov |
1 to 10 of 965
See all 965 trialsNIH grants1,680
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA1D papers | Newest fiscal year |
|---|---|---|---|
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 19 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 10 | 2025 |
| R01DK043140 | Mechanisms Leading to Adrenal Zonation | 9 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 6 | 2025 |
| R01EY026817 | Calcium channels in retinal photoreceptors | 6 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 6 | 2025 |
| R01HL135109 | Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation | 6 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,680Source NIH's project files
See all 1,680 nih grantsPapers2,356
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated bioinformatics analysis of chromosomal deletion regions in glioblastoma identifies key genes linked to GABA(A) receptor signaling. | J Biomol Struct Dyn | 2026 | 42752294 | PubTator, text mining | PubMed |
| Emerging genetics of sleep and circadian disorders. | Curr Opin Pediatr | 2026 | 42750652 | PubTator, text mining | PubMed |
| Molecular basis for a Ca2+ binding hierarchy in the EF-hand motifs of CaBP2. | J Biol Chem | 2026 | 42648358 | PubTator, text mining | PubMed |
| Splicing Factor SF3B2 Regulates Cardiomyocyte Calcium Handling Through Alternative Splicing of Cardiac Ion Channel Genes. | bioRxiv | 2026 | 42619934 | PubTator, text mining | PubMed |
| Rare germline variants in canonical and candidate genes in apparently sporadic bilateral primary aldosteronism. | J Endocr Soc | 2026 | 42577001 | PubTator, text mining | PubMed |
| Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling. | Proc Natl Acad Sci U S A | 2026 | 42546191 | PubTator, text mining | PubMed |
| [Primary aldosteronism as an independent factor of kidney damage. Potential therapeutic strategies and research prospects]. | Probl Endokrinol (Mosk) | 2026 | 42545319 | PubTator, text mining | PubMed |
| Coordinated Transcriptional Repression of CAV1 and CAV2 in Thoracic Aortic Aneurysm: A microRNA Regulatory Network Analysis. | Genes (Basel) | 2026 | 42510867 | PubTator, text mining | PubMed |
| Caveolae in cancer: mechanochemical signaling in tumor progression, immunity, and therapy. | Cell Commun Signal | 2026 | 42482076 | PubTator, text mining | PubMed |
| Impact of CaV1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer. | Int J Mol Sci | 2026 | 42449938 | PubTator, text mining | PubMed |
1 to 10 of 2,356
See all 2,356 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/776
GET https://conductscience.org/api/genes/v1/776/patents?page=2