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Gene · 777

CACNA1E: calcium voltage-gated channel subunit alpha1 E

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1E: calcium voltage-gated channel subunit alpha1 E. Genes, record 777. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/777

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Gene

Symbol
CACNA1E
HGNC
Name
calcium voltage-gated channel subunit alpha1 E
HGNC
NCBI Gene ID
777
NCBI Gene
HGNC ID
HGNC:1392
HGNC
Ensembl
ENSG00000198216
NCBI Gene
Aliases
BII, CACH6, CACNL1A6, Cav2.3, DEE69, EIEE69, gm139
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15878Voltage-dependent R-type calcium channel subunit alpha-1E2,3135Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026511339 A2026-04-147Q15878Espacenet
JP 2026004568 A2026-01-1439672Q15878Espacenet
EP 4641201 A22025-10-2923486Q15878Espacenet
EP 4641201 A22025-10-298434Q15878Espacenet
JP 2025529142 A2025-09-04691Q15878Espacenet
US 12371689 B22025-07-29691Q15878Espacenet
JP 2025517969 A2025-06-128434Q15878Espacenet
JP 2025517969 A2025-06-1223486Q15878Espacenet
JP 2025062604 A2025-04-1410780Q15878Espacenet
JP 2025062604 A2025-04-1410783Q15878Espacenet

1 to 10 of 26

See all 26 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
PHLOROGLUCINOLCHEMBL473159Voltage-gated calcium channel blockerBLOCKERChEMBL
PREGABALINCHEMBL1059Voltage-gated calcium channel modulatorMODULATORChEMBL
SULOCTIDILCHEMBL404849Voltage-gated calcium channel blockerBLOCKERChEMBL
TERODILINECHEMBL363295Voltage-gated calcium channel blockerBLOCKERChEMBL

1 to 10 of 11

See all 11 drugs

Trials370

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,348

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1E papersNewest fiscal year
P30CA054174Mays Cancer Center at UT Health SA82025
P30CA016672Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)42025
R01NS055251Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors42025
P30CA008748Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
R01NS116694Validation of Spinal Neurotensin Receptor 2 as an Analgesic Target32025
R35GM122523Molecular Mechanisms of Cell Signaling32025
R35GM141802Voltage-gated calcium channels as target for anesthetics32025
ZIAHD008755Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons32025

1 to 10 of 1,348Source NIH's project files

See all 1,348 nih grants

Papers1,577

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin.Int J Mol Sci202642794641PubTator, text miningPubMed
Efficacy of synthetic ACTH in confirmed and presumed monogenic developmental and epileptic encephalopathies.Epileptic Disord202642615235PubTator, text miningPubMed
A novel CACNA1E mutation (c.1256G > A) was identified in a Chinese patient with epilepsy and congenital heart disease.Front Med (Lausanne)202642553611PubTator, text miningPubMed
Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy.Neuroscience202642392563PubTator, text miningPubMed
The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications.J Cancer202642327581PubTator, text miningPubMed
Reduction of CACNA1D-Associated Catatonia Symptoms in an Adolescent With Concurrent Severe Autism Spectrum Disorder: A Case Report.J ECT202642218824PubTator, text miningPubMed
Deacetyl Ophiopojaponin A ameliorates Asthma by Inhibiting L-Type Calcium Channel Cav2.3 to Reduce Calcium Load in Airway Epithelial Cells.J Inflamm Res202642169749PubTator, text miningPubMed
Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing.Elife202642138352PubTator, text miningPubMed
Characterization of Three Distinct Loss-of-Function Cav2.3 Variants.Int J Mol Sci202642123681PubTator, text miningPubMed
The importance of genetic testing in managing developmental epileptic encephalopathy in resource-limited settings: a case report.J Med Case Rep202642098868PubTator, text miningPubMed

1 to 10 of 1,577

See all 1,577 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/777

GET https://conductscience.org/api/genes/v1/777/patents?page=2