Gene · 777
CACNA1E: calcium voltage-gated channel subunit alpha1 E
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA1E: calcium voltage-gated channel subunit alpha1 E. Genes, record 777. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/777
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15878 | Voltage-dependent R-type calcium channel subunit alpha-1E | 2,313 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026511339 A | 2026-04-14 | 7 | Q15878 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 39672 | Q15878 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 23486 | Q15878 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8434 | Q15878 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 691 | Q15878 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 691 | Q15878 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8434 | Q15878 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23486 | Q15878 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10780 | Q15878 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10783 | Q15878 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs11
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL HYDROCHLORIDE | CHEMBL1200382 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| GABAPENTIN | CHEMBL940 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| GABAPENTIN ENACARBIL | CHEMBL1628502 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| IMAGABALIN | CHEMBL2103836 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| PHLOROGLUCINOL | CHEMBL473159 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| PREGABALIN | CHEMBL1059 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| SULOCTIDIL | CHEMBL404849 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| TERODILINE | CHEMBL363295 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
1 to 10 of 11
See all 11 drugsTrials370
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07344467 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230197 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230171 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07208357 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07196657 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07186751 | PREGABALIN | ClinicalTrials.gov |
1 to 10 of 370
See all 370 trialsNIH grants1,348
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA1E papers | Newest fiscal year |
|---|---|---|---|
| P30CA054174 | Mays Cancer Center at UT Health SA | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| R01NS055251 | Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| R01NS116694 | Validation of Spinal Neurotensin Receptor 2 as an Analgesic Target | 3 | 2025 |
| R35GM122523 | Molecular Mechanisms of Cell Signaling | 3 | 2025 |
| R35GM141802 | Voltage-gated calcium channels as target for anesthetics | 3 | 2025 |
| ZIAHD008755 | Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons | 3 | 2025 |
1 to 10 of 1,348Source NIH's project files
See all 1,348 nih grantsPapers1,577
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin. | Int J Mol Sci | 2026 | 42794641 | PubTator, text mining | PubMed |
| Efficacy of synthetic ACTH in confirmed and presumed monogenic developmental and epileptic encephalopathies. | Epileptic Disord | 2026 | 42615235 | PubTator, text mining | PubMed |
| A novel CACNA1E mutation (c.1256G > A) was identified in a Chinese patient with epilepsy and congenital heart disease. | Front Med (Lausanne) | 2026 | 42553611 | PubTator, text mining | PubMed |
| Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy. | Neuroscience | 2026 | 42392563 | PubTator, text mining | PubMed |
| The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications. | J Cancer | 2026 | 42327581 | PubTator, text mining | PubMed |
| Reduction of CACNA1D-Associated Catatonia Symptoms in an Adolescent With Concurrent Severe Autism Spectrum Disorder: A Case Report. | J ECT | 2026 | 42218824 | PubTator, text mining | PubMed |
| Deacetyl Ophiopojaponin A ameliorates Asthma by Inhibiting L-Type Calcium Channel Cav2.3 to Reduce Calcium Load in Airway Epithelial Cells. | J Inflamm Res | 2026 | 42169749 | PubTator, text mining | PubMed |
| Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing. | Elife | 2026 | 42138352 | PubTator, text mining | PubMed |
| Characterization of Three Distinct Loss-of-Function Cav2.3 Variants. | Int J Mol Sci | 2026 | 42123681 | PubTator, text mining | PubMed |
| The importance of genetic testing in managing developmental epileptic encephalopathy in resource-limited settings: a case report. | J Med Case Rep | 2026 | 42098868 | PubTator, text mining | PubMed |
1 to 10 of 1,577
See all 1,577 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/777
GET https://conductscience.org/api/genes/v1/777/patents?page=2