ConductScience.org, home

Gene · 779

CACNA1S: calcium voltage-gated channel subunit alpha1 S

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CACNA1S: calcium voltage-gated channel subunit alpha1 S. Genes, record 779. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/779

On this page

Gene

Symbol
CACNA1S
HGNC
Name
calcium voltage-gated channel subunit alpha1 S
HGNC
NCBI Gene ID
779
NCBI Gene
HGNC ID
HGNC:1397
HGNC
Ensembl
ENSG00000081248
NCBI Gene
Aliases
CACNL1A3, CCHL1A3, CMYO18, CMYP18, Cav1.1, DHPRM, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13698Voltage-dependent L-type calcium channel subunit alpha-1S1,8732Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439649Q13698Espacenet
EP 4641201 A22025-10-298139Q13698Espacenet
JP 2025529142 A2025-09-04696Q13698Espacenet
US 12371689 B22025-07-29696Q13698Espacenet
JP 2025517969 A2025-06-128139Q13698Espacenet
JP 2025062604 A2025-04-1410758Q13698Espacenet
JP 2025510310 A2025-04-141Q13698Espacenet
KR 1020240163152 A2024-11-181Q13698Espacenet
US 12077582 B22024-09-038Q13698Espacenet
US 11492400 B22022-11-088Q13698Espacenet

1 to 10 of 21

See all 21 patents

Drugs45

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMLODIPINECHEMBL1491Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BENZOATECHEMBL4594262Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE BESYLATECHEMBL1200402Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AMLODIPINE MALEATECHEMBL1200984Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
AZD1305CHEMBL3545169Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
AZELNIDIPINECHEMBL1275868Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BARNIDIPINECHEMBL2103761Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BENIDIPINECHEMBL2074972Voltage-gated L-type calcium channel blockerBLOCKERChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL

1 to 10 of 45

See all 45 drugs

Trials965

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,381

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1S papersNewest fiscal year
R01AR063182Disease Pathogenesis and Modification for CaV1.1-Associated Hypokalemic Periodic Paralysis92025
T32AR007592Interdisciplinary Training Program in Muscle Biology72025
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]72025
P30AG021332Wake Forest Claude D. Pepper OAIC - Renewal62025
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity52025
R01HL112808Structural Basis for Antiarrhythmic Drug Action52025
R01HL140934Exploring the Molecular Physiology of Atrial Fibrillation52025
ZIAHG200359Genomic Ascertainment - Molecular and Genetic Aspects52025
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy42025
P30CA076292Moffitt Cancer Center Support Grant42025

1 to 10 of 1,381Source NIH's project files

See all 1,381 nih grants

Papers2,128

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Estimating the Prevalence of Malignant Hyperthermia Susceptibility Based on Causative RYR1 and CACNA1S Variants.Int J Mol Sci202642794754PubTator, text miningPubMed
A New Disease Gene for Hypokalemic Periodic Paralysis, KCNA7 , Established in a Multigenerational Family.bioRxiv202642780157PubTator, text miningPubMed
Generation of two human induced pluripotent stem cell lines from patients with hypokalemic periodic paralysis.Stem Cell Res202642759100PubTator, text miningPubMed
A novel CACNA1S variant associated with diltiazem-related worsening of hypokalemic periodic paralysis: a case report.Neurol Sci202642637926PubTator, text miningPubMed
Molecular genetics of skeletal muscle diseases associated with abnormal excitation-contraction coupling.J Hum Genet202642572084PubTator, text miningPubMed
Managing Secondary Findings from Germline Pharmacogenomic Testing.J Pers Med202642506114PubTator, text miningPubMed
Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail.J Gen Physiol202642479471PubTator, text miningPubMed
The genetic basis of over-retained deciduous teeth and delayed permanent tooth eruption: A systematic review.Am J Orthod Dentofacial Orthop202642446440PubTator, text miningPubMed
Gene Panel Analysis Reveals Overlapping Genetic Causes of Inherited Cataracts and Other Ocular Phenotypes in Bulgarian Patients.Mol Genet Genomic Med202642360812PubTator, text miningPubMed
Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra-Rare CACNA1S Variant.Clin Case Rep202642256938PubTator, text miningPubMed

1 to 10 of 2,128

See all 2,128 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/779

GET https://conductscience.org/api/genes/v1/779/patents?page=2